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ENDo-HERPES

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Endogenous Human Herpesvirus: Germ line integration and effects on host cell and...

Endogenous Human Herpesvirus: Germ line integration and effects on host cell and organism Endogenous viruses present in the human genome control physiological processes, modulate aging, and can cause diseases. Intriguingly, a herpesvirus has entered the human germ line by integrating its genome into telomeres of germ c... ver más

31/08/2028

Freie Universitaet...

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

FREIE UNIVERSITAET BERLIN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-09-01

ERC-2022-COG: ERC CONSOLIDATOR GRANTS Scope:Objectives

I+D

Cerrada hace 2 años

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

Participantes

Freie Universitaet Berlin

Lider

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Duración del proyecto: 59 meses Fecha Inicio: 2023-09-01
Fecha Fin: 2028-08-31

Líder del proyecto

FREIE UNIVERSITAET BERLIN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Endogenous viruses present in the human genome control physiological processes, modulate aging, and can cause diseases. Intriguingly, a herpesvirus has entered the human germ line by integrating its genome into telomeres of germ cells and is present in about 80 million people. The virus, human herpesvirus 6 (HHV-6), can reactivate from the integrated state, which is associated with a number of diseases. These include seizures, encephalitis, heart failure and graft rejection. We recently analysed the virus genomes present in hundreds of individuals with this inherited chromosomally-integrated HHV-6 (iciHHV-6). The data show that today’s endogenous virus sequences are quite diverse and derived from dozens of independent integration events that were passed on for generations. There are critical gaps in our knowledge on the functionality of iciHHV-6 genomes with respect to virus replication, gene expression and latency, its effects on the host cell, and the role of telomere shortening that occurs during aging on virus reactivation. ENDo-HERPES will make use of novel technology to close these gaps and provide the basis for elucidating whether diseases are associated with or caused by iciHHV-6. Specifically, we will 1) identify which iciHHV-6 genomes are still functional and could contribute to disease development; 2) determine iciHHV-6 integration sites within the highly repetitive telomere region and assess the integration and reactivation process on the DNA level; and 3) investigate the effects of the iciHHV-6 genome on host cells and if telomere shortening can induce reactivation. The proposal utilizes state-of-the-art technology and pioneers new approaches, particularly when investigating the integration sites of endogenous virus genomes and the mechanisms facilitating integration and reactivation. Altogether, we will shed light on the life cycle and effects on the host cells of this endogenous herpesvirus present in the genome of about 1% of the human population.

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