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ANION_CAGES

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Dynamic Constitutional Chemistry for the Preparation of Receptors for Anions of...

Dynamic Constitutional Chemistry for the Preparation of Receptors for Anions of Biological Interest From chloride to DNA, over 75% of the cofactors and bio-molecules have negative charge at physiological pH. However, efficient synthetic receptors for anionic entities in aqueous solution have attracted lesser attention than ligan... ver más

30/09/2016

CSIC

100K€

Presupuesto del proyecto: 100K€

Líder del proyecto

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 2-3 | 552M€

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2016-09-30 No tenemos la información de la convocatoria

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

CSIC

0.00€ | Lider

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Líder del proyecto

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 2-3 | 552M€

Presupuesto del proyecto 100K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto From chloride to DNA, over 75% of the cofactors and bio-molecules have negative charge at physiological pH. However, efficient synthetic receptors for anionic entities in aqueous solution have attracted lesser attention than ligands for cationic or neutral species. The intrinsic physicochemical problems of anion binding and the molecular diversity of anionic species have often hampered this research field. In this project, the identification and synthesis of new molecular receptors for anions with biological relevance is proposed. To this aim, we will use a constitutional dynamic chemistry approach, a conceptually new methodology based on the molecular evolution idea. Thus, we will prepare a dynamic library of components interconnected through exchange by chemical equilibriums. These building blocks will bear a molecular recognition moiety able to bind anions, and the required functional group(s) for the establishment of a covalent bond under reversible conditions. In the presence of the target entity (an anionic template), the dynamic system will evolve to efficiently interact with the template and the best binder will be amplified and identified. As the building blocks, we will use peptide-like molecular architectures, since they can bear different potential anion binding functions (amide, ammonium, etc…), show large molecular and structural diversity and, in general, display good biological tolerance. Additionally, their synthetic, isolation and characterization procedures are quite straightforward. Using this rationale with anionic templates of biological importance, this methodology will allow us to synthesize new receptors of biologically interesting molecules with increased binding abilities, which will be finally tested for the corresponding biological functions. Therefore, if successful, this project will mean an important methodological breakthrough in anion recognition chemistry.

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