PADMME
Financiado
Dual-channel paper-based electroanalytical platform for multiple myeloma care
Multiple myeloma (MM) is an aggressive type of cancer of plasma cells where fast diagnosis and treatment monitoring is vital, especially given the overall low survival rate. Proteasome, a multi-catalytic complex essential in damag...
Multiple myeloma (MM) is an aggressive type of cancer of plasma cells where fast diagnosis and treatment monitoring is vital, especially given the overall low survival rate. Proteasome, a multi-catalytic complex essential in damaged protein degradation, has been recently established as a biomarker for MM, in which elevated levels have been observed in blood plasma of unhealthy individuals, as well as its impaired activity has been target for treatment alongside regular chemotherapy. PADMME addresses increasing contributions on proteasome electrochemical recognition and aims to develop novel interdisciplinary technologies translatable into POCT systems for MM care. For this, we propose the development of sensitive and selective dual-channel platforms comprising conductive polymeric fiber biosensors integrated on paper-based microfluidic supports to simultaneously detect quantity and specific activity of proteasome in blood plasma. Paper supports ensure disposability and ease of commercialization, whilst incorporation of microfluidic paths allows low sample volume requirements and in situ pre-treatment steps. Conductive polymeric fiber scaffolds provide increased signal resolution for the construction of biosensors, necessary for the recognition of low concentrations of the biomarker. Then, investigating proteasome at the dual-channel platform in drug-treated and untreated MM cell lines will demonstrate how changes in quantity and specific activity are specifically linked to the disease dynamics. The last step will comprise validation of the technology for analysis in blood plasma, technology able to improve overall monitoring of MM disease progression and therapeutic efficiency, crucial to overcome delays in treatment due to drug resistance complications. Training through research will allow me to refine my expertise, creativity and innovative potential on smart biosensor technologies translated into point-of-care testing devices for cancer care and drug assessment.
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Duración del proyecto: 27 meses
Fecha Inicio: 2022-06-03
Fecha Fin: 2024-09-30
Fecha Fin: 2024-09-30
Línea de financiación: concedida
El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-09-30
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
Presupuesto
El presupuesto total del proyecto asciende a
134K€
Líder del proyecto
INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE P...
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