Innovating Works

DNAPC4ImunoMol

Financiado
DNA modules as communicators in tumor immunomodulation
Our goal is to develop all-DNA structures (protocells) that can act as modulators of the immune system and, in particular, of signaling processes in oncology. Molecular DNA switches that interact with cells via aptamers have been... Our goal is to develop all-DNA structures (protocells) that can act as modulators of the immune system and, in particular, of signaling processes in oncology. Molecular DNA switches that interact with cells via aptamers have been developed and used for drug delivery, cell imaging, and potential therapies. However, there are several advantages of incorporating these swithces into protocells, such as the protection of these circuits against degradation, the ability to create gradients and as a delviery method for in vivo application. DNA protocells that (i) have the ability to recognize proteins and small molecules and (ii) amplify signals and generate output that alters cell physiology have not yet been developed. Realizing these structures requires filling a gap in our knowledge of how of how aptamer reactions network in confinement. We anticipate that by filling these gaps in our knowledge, we will be able to produce a pure DNA protocell that can harbor aptamer-based response networks for modulation of intercelullar communication in the tumor microenvironment. ver más
30/04/2025
JOHANNES GUTENBERG...
174K€
Duración del proyecto: 25 meses Fecha Inicio: 2023-03-13
Fecha Fin: 2025-04-30

Línea de financiación: concedida

El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-03-13
Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:
HORIZON-MSCA-2022-PF-01-01: MSCA Postdoctoral Fellowships 2022
Cerrada hace 2 años
Presupuesto El presupuesto total del proyecto asciende a 174K€
Líder del proyecto
JOHANNES GUTENBERGUNIVERSITAT MAINZ No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico TRL 4-5