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CorPain

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Dissection of a cortical microcircuit for the processing of pain affect

It is a fundamental but still elusive question how nociceptive processing is performed in neuronal networks in the cortex for the conscious experience of pain. The objective of this project is to identify and characterize the cor... ver más

31/08/2021

UNIVERSITAET BERN

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

UNIVERSITAET BERN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2021-08-31

ERC-CoG-2015: ERC Consolidator Grant

I+D

Cerrada hace 9 años

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2 Participantes

UNIVERSITAET BERN

1.93M€ | Lider

SERVIBERICA

274.50K€ | Participante

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Duración del proyecto: 62 meses Fecha Inicio: 2016-06-20
Fecha Fin: 2021-08-31

Líder del proyecto

UNIVERSITAET BERN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Descripción del proyecto It is a fundamental but still elusive question how nociceptive processing is performed in neuronal networks in the cortex for the conscious experience of pain. The objective of this project is to identify and characterize the cortical microcircuits in the anterior cingulate cortex (ACC) that are involved in pain processing with cellular resolution. The ACC is essential for evaluating the emotional/affective component of pain. Our research will investigate the elusive question if a dedicated pain circuit exists in the ACC. We will dissect the detailed structure and connectivity of this pain circuit and investigate how it generates affective behavioural responses related to pain. At the core of this project, we will characterize the neuronal networks in the ACC that are engaged in the processing of noxious stimuli. It will be highly interesting to determine the neuronal dynamics in the ACC during nociception and in chronic pain conditions on the cellular and network level. Furthermore, we will elucidate the downstream targets that are influenced by the pain circuits in the ACC to generate the appropriate behavioural responses. These aims will be achieved by a combination of electrophysiology, 2-photon Ca2+ imaging and pharmaco- and opto-genetic approaches both in vivo and in vitro and behavioural testing of pain affect in mice. This project will give a comprehensive picture of how a cortical microcircuit processes afferent noxious stimuli to generate an affective behavioural response. This study will give important insight into the fundamental question of cortical information processing and it is highly relevant to understand pain processing and the changes in the network dynamics that manifest the transition to chronic pain. Eventually this might contribute to the development of novel treatment strategies for this pathological condition.

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