Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

PolyDomFormFuncReg

Financiado

Cerrado

Discovering how polycomb domains form and function in gene regulation

Polycomb group chromatin modifying systems are essential for normal gene regulation and development, and alterations in their activity are a hallmark of a broad range of cancers. Although the chromatin modifications placed by the... ver más

31/05/2021

UOXF

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UN... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2021-05-31

ERC-CoG-2015: ERC Consolidator Grant

I+D

Cerrada hace 9 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

UOXF

2.00M€ | Lider

ESPECIALIDADES PLASTICAS DEL...

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

REPODDID Regulation of Polycomb Complex PRC2 during development and... 1M€ Cerrado

BES-2017-081035 NUEVAS FUNCIONES DE LOS COMPLEJOS POLYCOMB EN REGULACION GEN... 93K€ Cerrado

PRCTOERC Novel Regulatory Principles of Polycomb Repressive Complex 2 1M€ Cerrado

DissectPcG Dissecting the Function of Multiple Polycomb Group Complexes... 2M€ Cerrado

SAF2013-48926-P NUEVAS FUNCIONES DE LAS PROTEINAS POLYCOMB EN EL DESARROLLO,... 484K€ Cerrado

WaddingtonMemory Deciphering the role of regulatory factors driving epigeneti... 2M€ Cerrado

Duración del proyecto: 62 meses Fecha Inicio: 2016-03-07
Fecha Fin: 2021-05-31

Líder del proyecto

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UN... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Polycomb group chromatin modifying systems are essential for normal gene regulation and development, and alterations in their activity are a hallmark of a broad range of cancers. Although the chromatin modifications placed by the two central polycomb protein complexes (PRC1 and PRC2) are well-characterized, how this fascinating system selects its target sites in vivo, and then forms polycomb chromatin domains that are repressive to transcription remains enigmatic. This constitutes the major conceptual gap in our understanding of this essential gene regulatory system. We recently discovered a new pathway that is sufficient in model systems to initiate polycomb chromatin domain formation. Building on this discovery, an ambitious high-risk/high-reward yet hypothesis-driven multidisciplinary approach integrating biochemical, molecular, genomic, and single-cell analyses will be exploited to discover the fundamental principles that underpin polycomb domain formation and subsequently transcriptional repression. Specifically, the three aims of the research programme are to: (i) Discover how the KDM2B/PRC1 complex initiates polycomb domain formation, (ii) Discover how polycomb target sites are selected and polycomb domains formed during normal cell lineage commitment, and (iii) Discover how polycomb domains regulate gene expression. Going well beyond the state-of-the-art, our innovative approaches will lead to major new breakthroughs closing the conceptual gap that currently limits our understanding of how polycomb complexes regulate gene expression, an essential first step towards the possibility of devising strategies for therapeutic intervention in human cancers and other diseases where these systems are perturbed. Furthermore, support from the ERC in tackling these important problems will allow me to recruit the talented individuals necessary to achieve our objectives and consolidate my position as an emerging leader in the field.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores