Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

CHROMATIN DOMAINS

Financiado

Cerrado

Differentially Accessible Chromatin Domains and Their Transcriptional Regulatory...

Differentially Accessible Chromatin Domains and Their Transcriptional Regulatory Role in Health and Disease The human genome encodes for hundreds of transcriptional programs, which facilitates the unique functions and morphologies presented by different cell types. Only recently, the role of DNA packaging into chromatin emerged as one o... ver más

31/08/2017

THE HEBREW UNIVERS...

100K€

Presupuesto del proyecto: 100K€

Líder del proyecto

THE HEBREW UNIVERSITY OF JERUSALEM No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2017-08-31 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

THE HEBREW UNIVERSITY OF JER...

0.00€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

CISREGLOGIC Identifying and understanding the cis regulatory modules tha... 187K€ Cerrado

MuG Multi Scale Complex Genomics 3M€ Cerrado

PID2020-119715GB-I00 DESCUBRIMIENTO DE LAS PALABRAS EPIGENETICAS DE LA REGULACION... 105K€ Cerrado

PRIMATE_REG_EVOL A comparative genomic study of the contribution of epigeneti... 236K€ Cerrado

DeCRyPT Deciphering Cis Regulatory Principles of Transcriptional reg... 2M€ Cerrado

GENEREGULATION Deciphering the code of gene regulation using massively para... 2M€ Cerrado

Líder del proyecto

THE HEBREW UNIVERSITY OF JERUSALEM No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 100K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The human genome encodes for hundreds of transcriptional programs, which facilitates the unique functions and morphologies presented by different cell types. Only recently, the role of DNA packaging into chromatin emerged as one of the major contributors to the modularity and dynamics of the genome. Here, I propose to harness my computational expertise with vast amounts of publicly available data in mice and humans, and study the internal modularity and dynamics of genome packaging, and its relation to the expression levels of underlying genes in various conditions. Specifically, the objectives of this proposal are fourfold: (1) Identify chromatin domains at a genome-wide scale. I will analyze data from hundreds of genome-wide chromatin tracks, and develop computational algorithms to segment the genome into atomic units of chromatin packaging, that open and close as homogenous blocks under various conditions and transcriptional programs. (2) Annotate and understand the functional roles of each domain. I will utilize public gene expression data and genomic maps of chromatin modifiers to annotate the role of each chromatin block, and construct an unbiased comprehensive map of the genome packaging. (3) Study the mechanisms that define, maintain and modify chromatin domains. Using sequence motifs and published binding data, I will identify chromatin regulators involved in differential domains. (4) The role of aberrant chromatin packaging in cancerous tissues. I will contrast the above domains with chromatin in cancerous tissues, and link differences to transcriptional abnormalities, thus producing a detailed set of testable hypotheses regarding the mechanisms and progression of tumors. With proven experience and proven background in genomics and computation and algorithms, I am poised to significantly contribute to our understanding of genome packaging and transcriptional regulation.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores