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Developmental Origins exploring the Nature Nurture Interplay

The Developmental Origins of Health and Disease (DOHaD) hypothesis states that insults in early life can have lifelong, irreversible impacts, affecting individuals’ health and well-being in older age. My proposed research builds o... ver más

31/08/2025

UNIVERSITY OF BRIS...

1M€

Presupuesto del proyecto: 1M€

Líder del proyecto

UNIVERSITY OF BRISTOL No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

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Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2019-10-07

ERC-2019-STG: ERC Starting Grant

I+D

Cerrada hace 6 años

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No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

UNIVERSITY OF BRISTOL

1.50M€ | Lider

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Duración del proyecto: 70 meses Fecha Inicio: 2019-10-07
Fecha Fin: 2025-08-31

Líder del proyecto

UNIVERSITY OF BRISTOL No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 1M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The Developmental Origins of Health and Disease (DOHaD) hypothesis states that insults in early life can have lifelong, irreversible impacts, affecting individuals’ health and well-being in older age. My proposed research builds on this in two main ways. First, I will use natural experiments to investigate the causal impact of early life circumstances on later life outcomes, focusing on novel (1) nutritional, (2) toxicological, (3) health and (4) economic environments in early life. Within these, I will consider insults (i) for which there is insufficient knowledge of their long-term impacts, (ii) which are relevant today, and (iii) importantly, which are modifiable. Second, I will go beyond the old nature versus nurture debate and investigate how individuals’ genes (‘nature’) interacts with the above early life environments (‘nurture’) in creating inequalities in health and well-being. Whilst neither the estimation of causal effects within DOHaD, nor the estimation of the gene-environment (GxE) interplay is new, their combination is. Indeed, it is currently not known how the early life environment interacts with genetic predisposition to causally shape later life outcomes, as well as whether certain environments exacerbate or reduce health inequalities in the population. Combining advancements across disciplines, I will evaluate the long-term effects of short-term variations in early life conditions (objective 1), and I will directly test the hypothesis that gene-environment interactions causally shape later life outcomes (objective 2). I will digitize historical data on early life environmental exposures and merge these with large-scale individual-level data. As such, my proposal will investigate the extent to which genes interact with the environment, using natural experiments to identify interventions that can ameliorate inequalities in health and well-being (objective 3).

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