Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

CANCERPATHWAYS

Financiado

Cerrado

Developmental Molecular Pathways in Drosophila as a Model for Human Cancer

Cancer is often characterized as a disease of signal transduction pathways, since it is frequently associated with inappropriate activation of such pathways. Indeed, new therapeutic approaches in cancer therapy, such as Herceptin,... ver más

31/10/2011

GERMAN CANCER RESE...

4M€

Presupuesto del proyecto: 4M€

Líder del proyecto

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 9 Participantes

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2011-10-31 No tenemos la información de la convocatoria

0% 67% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

9 Participantes

GERMAN CANCER RESEARCH CENTE...

0.00€ | Lider

UMH

N.D. | Participante

FORSCHUNGSINSTITUT FUR MOLEK...

N.D. | Participante

USFD

N.D. | Participante

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

TWSCC Trafficking of Wnt Signaling Components in Cancer 163K€ Cerrado

OncoResist Genetic and epigenetic resistance to oncogenic transformatio... 160K€ Cerrado

ONCOMIRS MicroRNAs and Cancer From Bench to Bedside 4M€ Cerrado

SAF2012-35181 IDENTIFICACION DE MECANISMOS CAUSANTES DE CANCER Y METASTASI... 445K€ Cerrado

BFU2009-09074 IDENTIFICACION DE MECANISMOS CAUSANTES DE CANCER Y METASTASI... 593K€ Cerrado

BFU2008-03320 MECANISMOS CELULARES Y MOLECULARES DE LA SEÑALIZACION DE HED... 386K€ Cerrado

Líder del proyecto

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 4M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Cancer is often characterized as a disease of signal transduction pathways, since it is frequently associated with inappropriate activation of such pathways. Indeed, new therapeutic approaches in cancer therapy, such as Herceptin, frequently target signaling pathway components to revert their pathophysiological aberrations. Most oncogenic pathways have been highly conserved throughout evolution with Drosophila representing a particularly powerful genetic model for the analysis of such signaling cascades. These cancer pathways include Wnt, Notch, Hippo and JAK/STAT pathways. The analysis of signaling pathways in Drosophila is facilitated by the availability of a broad range of genetic tools, a completely sequenced genome and the availability of genome-wide collections of RNAi reagents. Within this project, we will establish high-throughput cell-based assays for regulators of the major developmental oncogenic signaling pathways. Cell-based assays for signaling pathways will be screened using genome-wide RNAi and small molecule compound libraries to identify new components, regulators and targets. Suppressor/enhancer screens in cultured cells will be used to identify small molecular compounds that interfere with the activity of specific signaling pathways and in vivo models of signaling pathways will be established to test the activity of drugs using developmental and tumorogenic phenotypes. By integrating and standardizing data from most important cancer relevant signaling pathways and combining them with powerful bioinformatics tools, we expect to get highly validated information on possible drug targets and lead substances. The collaborative project integrates recent technological advances, such as genome-wide RNAi libraries for cell-based and in vivo assay models that were developed by the participants, as well as computational approaches and databases to integrate and disseminate the information obtained during the project.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores