Developmental immunotoxicity of perfluoroalkyl substances (PFASs) in a populatio...
Developmental immunotoxicity of perfluoroalkyl substances (PFASs) in a population of highly-exposed children
Exposures to perfluoroalkyl substances (PFASs), a class of persistent chemicals, have been linked to an array of adverse health outcomes including reduced antibody response to vaccination. The COVID-19 pandemic has focused attent...
ver más
EPIC
Exploring the PFAS alternatives-induced immunotoxicity and i...
166K€
Cerrado
ENDOMIX
Understanding how endocrine disruptors and chemical mixtures...
6M€
Cerrado
AGL2009-09061
EVALUACION DE LA TOXICIDAD NEUROENDOCRINA DE COMPUESTOS ORGA...
97K€
Cerrado
MANGO
The chemical exposoMe of pregnAnt womeN with GestatiOnal dia...
261K€
Cerrado
PID2019-104443GB-I00
EXPOSICION TEMPRANA A SUSTANCIAS QUIMICAS A TRAVES DE MATERI...
97K€
Cerrado
PID2020-113812RB-C32
CONTAMINANTES AMBIENTALES, FENOTIPO AUTISTA Y ENVEJECIMIENTO
145K€
Cerrado
Últimas noticias
30-11-2024:
Cataluña Gestión For...
Se ha cerrado la línea de ayuda pública: Gestión Forestal Sostenible para Inversiones Forestales Productivas para el organismo:
29-11-2024:
IDAE
En las últimas 48 horas el Organismo IDAE ha otorgado 4 concesiones
29-11-2024:
ECE
En las últimas 48 horas el Organismo ECE ha otorgado 2 concesiones
Descripción del proyecto
Exposures to perfluoroalkyl substances (PFASs), a class of persistent chemicals, have been linked to an array of adverse health outcomes including reduced antibody response to vaccination. The COVID-19 pandemic has focused attention on the serious implications of PFAS immunotoxicity. However, there is a lack of epidemiological studies on clinical immune outcomes (e.g., infections or asthma) in children, whose developing immune system is highly sensitive to chemical exposures. This proposal (PFAS-ITOX) addresses this research gap by leveraging a unique cohort of children with a wide range of PFAS exposures (background to highly exposed) and detailed medical records to investigate the potential immunotoxic effects of prenatal and childhood PFAS exposures on clinically relevant outcomes, including COVID-19 incidence.
It was discovered in 2013 that one of two municipal water supplies in Ronneby, Sweden was delivering water that was highly contaminated by PFASs from firefighting foam runoff at a nearby military airport. Earlier studies in Ronneby found that serum PFAS concentrations corresponded closely with residential address history, allowing residential history to be used as an accurate proxy for exposure. PFAS-ITOX uses this natural experiment to create a longitudinal cohort of children and evaluate whether high PFAS exposures are associated with clinical outcomes related to immunosuppression (e.g., counts of common childhood infections) and hypersensitivity (e.g., incidence of asthma). While existing studies of PFAS immunotoxicity rely on self-reported data or hospital admission records, I will use the Skåne Healthcare Register, unique to southern Sweden, to identify outcomes at all levels of care, including primary care where many immune outcomes are diagnosed. The proposal's results will inform future PFAS research, provide necessary evidence for risk assessments, and provide critical information to health practitioners caring for highly-exposed individuals.
Seleccionando "Aceptar todas las cookies" acepta el uso de cookies para ayudarnos a brindarle una mejor experiencia de usuario y para analizar el uso del sitio web. Al hacer clic en "Ajustar tus preferencias" puede elegir qué cookies permitir. Solo las cookies esenciales son necesarias para el correcto funcionamiento de nuestro sitio web y no se pueden rechazar.
Cookie settings
Nuestro sitio web almacena cuatro tipos de cookies. En cualquier momento puede elegir qué cookies acepta y cuáles rechaza. Puede obtener más información sobre qué son las cookies y qué tipos de cookies almacenamos en nuestra Política de cookies.
Son necesarias por razones técnicas. Sin ellas, este sitio web podría no funcionar correctamente.
Son necesarias para una funcionalidad específica en el sitio web. Sin ellos, algunas características pueden estar deshabilitadas.
Nos permite analizar el uso del sitio web y mejorar la experiencia del visitante.
Nos permite personalizar su experiencia y enviarle contenido y ofertas relevantes, en este sitio web y en otros sitios web.