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Dendrimmuneassays

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Development of sophisticated dendrimeric nanostructural materials with potential...

Development of sophisticated dendrimeric nanostructural materials with potential applications in drug allergy diagnosis Towards immunoassays and cellular tests basophil activation tests Nowadays drug allergy is considered a major public health problem in developed countries. Its correct diagnosis is very important for the adequate prescription of drugs to avoid risks for the patient. However, the adequate diagnos... ver más

26/01/2015

FUNDACIÓN INSTITUT...

169K€

Presupuesto del proyecto: 169K€

Líder del proyecto

FUNDACIÓN INSTITUTO MEDITERRÁNEO PARA EL AVAN... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5 | 6M€

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2015-01-26 No tenemos la información de la convocatoria

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Líder del proyecto

FUNDACIÓN INSTITUTO MEDITERRÁNEO PARA EL AVAN... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5 | 6M€

Presupuesto del proyecto 169K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Nowadays drug allergy is considered a major public health problem in developed countries. Its correct diagnosis is very important for the adequate prescription of drugs to avoid risks for the patient. However, the adequate diagnosis is in certain cases difficult to address. This research aims at the development of sophisticated nanostructural materials with potential applications in drug allergy diagnosis. To this, the study will first focus on the identification of drug antigenic determinants still unknown by using different drug models as those derived from diclofenac and clavulanic acid, by a synthetic strategy to the hypothesized molecules and subsequent clinical evaluation. Secondly we propose the design of dendritic molecules displaying multiple presentations of relevant drug antigenic determinants. The determinants identified in the objective above and others already known as amoxicillin, will be coupled to the periphery of dendrimers and/or dendrons with the adequate methodology. The molecular recognition of these structures by specific IgE antibodies will be evaluated by radioimmunoassays, and performances in the structures will be carried out up to reach an optimal recognition. The final well-recognized structures will be anchored onto a solid phase with the aim of developing drug allergy diagnostic kits, to use in a routine clinical practice. Other approaches towards the study of the optimal distance in crosslink-IgE to produce the basophil activation will also be addressed in order to increase the sensitivity of this test. Biocompatible dendrimer as scaffolds, click chemistry methodologies, solid phases, organic chemical design will be used for the development of this project, with an important support of clinical evaluation and a biobank with patients sera. This methodology is expected to deliver a new tool box for the design of sophisticated nanostructural materials and versatile to the diagnosis of allergy to different drugs towards a microarray.

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