Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

Multi-Islet

Financiado

Cerrado

Development of Multiscale Analysis of Pancreatic Beta Cell Function by Imaging I...

Development of Multiscale Analysis of Pancreatic Beta Cell Function by Imaging Islets in situ within the Intact Pancreas Type 2 diabetes is a global and costly healthcare problem associated with impaired insulin secretion from pancreatic beta-cells as well as peripheral insulin resistance. The range of complications associated with aberrant glucose... ver más

28/02/2014

IMPERIAL COLLEGE O...

200K€

Presupuesto del proyecto: 200K€

Líder del proyecto

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND ME... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2014-02-28 No tenemos la información de la convocatoria

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

IMPERIAL COLLEGE OF SCIENCE...

0.00€ | Lider

Proyectos interesantes

OptoBETA

Medical Technol...

Data Science

2M€ Cerrado

HuPIPA

Medical Technol...

Data Science

165K€ Cerrado

SAF2017-86242-R

Medical Technol...

Data Science

182K€ Cerrado

INSIGHT

Medical Technol...

Data Science

2M€ Cerrado

SAF2008-02536

Medical Technol...

Data Science

163K€ Cerrado

SAF2017-85619-R

Medical Technol...

Data Science

242K€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Líder del proyecto

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND ME... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 200K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Type 2 diabetes is a global and costly healthcare problem associated with impaired insulin secretion from pancreatic beta-cells as well as peripheral insulin resistance. The range of complications associated with aberrant glucose homeostasis is vast, and some severely impact the ability of diabetes-sufferers to lead a normal life. Despite significant research funding over the past three decades, the incidence of diabetes continues to grow. The finding in recent years that genes predispose to diabetes has ignited a search for the mechanisms through which diabetes-associated genes predispose to diabetes. At the single cell level, gene-silencing/transduction studies using cell cultures have shown that gene polymorphisms consistently associated with diabetes, such as those for TCF7L2, lead to defects in insulin processing, storage and secretion. At the whole-animal level, beta-cell specific deletion of TCF7L2 leads to marked glucose intolerance. Yet, directly extrapolating findings between these two levels is complicated by the dependence of beta-cells on their tissue context for proper function. To overcome this obstacle, and adequately reconcile these observations, further studies are required to assess how type 2 diabetes-associated genes alter beta-cell function at the single cell and population levels in the intact tissue. By applying multiphoton imaging and optogenetics to murine models of type 2 diabetes, new insights into the influence of identified risk genes on beta-cell behavior at multiple levels can be obtained. It is hoped that the findings stemming from these studies will allow new therapeutic targets to be identified in the future.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores