Developing Roles for Phosphates Outside of Biology: A Systems Chemistry Approach...
Developing Roles for Phosphates Outside of Biology: A Systems Chemistry Approach Towards Abiotic Phosphate Fuels
Phosphates and phosphate esters underpin biological information transfer, signal transduction, and contribute to the energetics of life. Biochemical fuels that include phosphates (ATP, GTP) drive selective processes, by incorporat...
Phosphates and phosphate esters underpin biological information transfer, signal transduction, and contribute to the energetics of life. Biochemical fuels that include phosphates (ATP, GTP) drive selective processes, by incorporating chemical information (A vs. G) in their fuel structure. Despite the multifaceted role of phosphates in biology, their use in supramolecular systems chemistry remains largely underexplored.
PhosphotoSupraChem develops roles for phosphates outside of biology and capitalizes on the idea of providing chemical information within abiotic phosphate fuels to control selectivity and reactivity in the context of fuel-driven structure formation. The information is provided by chemical functionalization of energy-rich phosphate fuels, whereby the information encode structural assembly of fuels prior to their consumption, or transfer large chemical groups onto self-assembling species during energy transfer. Specific aims are:
(i) Understand the chemical design space for phosphate fuel self-assembly and how such structures control selectivity and reactivity when transferring the energy for the formation of transient assemblies;
(ii) Construct fuels, capable of transferring structural information, enabling folding and chimeric dissipative self-assembly;
(iii) Promote waste-driven fuel formation, substrate release and peptide bond formation
(v) Involve fuels in automated synthesis for microfluidics materials discovery
PhosphotoSupraChem pioneers an unexplored area of science at the roots of dissipative systems and phosphate-driven systems chemistry. This strategy profoundly contrasts the present non-equilibrium self-assembly research featuring fuelling with molecules that lack structural and recognition elements. In the long term, fabricating biocompatible dissipative systems and developing automated platforms that guide fuels to specific functions will be a decisive step toward creating dynamic assemblies in vivo and programming active soft matter.ver más
Seleccionando "Aceptar todas las cookies" acepta el uso de cookies para ayudarnos a brindarle una mejor experiencia de usuario y para analizar el uso del sitio web. Al hacer clic en "Ajustar tus preferencias" puede elegir qué cookies permitir. Solo las cookies esenciales son necesarias para el correcto funcionamiento de nuestro sitio web y no se pueden rechazar.
Cookie settings
Nuestro sitio web almacena cuatro tipos de cookies. En cualquier momento puede elegir qué cookies acepta y cuáles rechaza. Puede obtener más información sobre qué son las cookies y qué tipos de cookies almacenamos en nuestra Política de cookies.
Son necesarias por razones técnicas. Sin ellas, este sitio web podría no funcionar correctamente.
Son necesarias para una funcionalidad específica en el sitio web. Sin ellos, algunas características pueden estar deshabilitadas.
Nos permite analizar el uso del sitio web y mejorar la experiencia del visitante.
Nos permite personalizar su experiencia y enviarle contenido y ofertas relevantes, en este sitio web y en otros sitios web.