Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

THYROREPRO

Financiado

Cerrado

Deciphering the role of thyroid hormones in seasonal reproduction

Most mammals living at temperate latitudes exhibit seasonal reproduction, which is synchronized by photoperiod through the central action of melatonin. In the ewe this translates into the initiation of the breeding season as day-l... ver más

31/07/2016

INRAE

100K€

Presupuesto del proyecto: 100K€

Líder del proyecto

INSTITUT NATIONAL DE RECHERCHE POUR LAGRICULT... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2016-07-31 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

INRAE

0.00€ | Lider

Proyectos interesantes

THYROMOL

Medical Technol...

Applied Physics

1M€ Cerrado

PGC2018-094630-B-I00

Medical Technol...

Applied Physics

145K€ Cerrado

PID2021-125846NB-I00

Medical Technol...

Applied Physics

194K€ Cerrado

MISS-SA

Medical Technol...

Applied Physics

174K€ Cerrado

PID2020-115829GB-I00

Medical Technol...

Applied Physics

94K€ Cerrado

GLUCOCLOCK

Medical Technol...

Applied Physics

100K€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Líder del proyecto

INSTITUT NATIONAL DE RECHERCHE POUR LAGRICULT... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 100K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Most mammals living at temperate latitudes exhibit seasonal reproduction, which is synchronized by photoperiod through the central action of melatonin. In the ewe this translates into the initiation of the breeding season as day-length shortens while the anestrus season is triggered by the photoperiod lengthening, which occurs at the end of winter. We recently characterized a complex pathway by which melatonin acts in the rostral part of the pituitary, known as the pars tuberalis, to yield a local increase of triiodothyronine (T3) within the adjacent medio-basal hypothalamus (MBH). This mechanism accounts for early observations that T3 increase within this region is mandatory for anestrus to occur. Building on these findings, this research program aims at a thorough characterization of the downstream events which ultimately tie the local increase in T3 to the shutdown of the gonadotropic axis. I propose a transcriptomics approach to reveal T3 target genes within the MBH and decipher how their photoperiodic control eventually impacts on the activity of GnRH neurons. Since the long-term objective of this work is to obtain out-of-season lambing without adverse hormonal treatments, the identification of T3 target genes will provide us with potential levers. The use of genetic databases in different ovine breeds presenting varying degrees of seasonality will help to assess the physiological role of these genes and lead to an improved genetic selection. The increase of T3 within the MBH requires the presence of its precursor, the thyroxine T4, in the cerebrospinal fluid. Since T4 gains access to the CSF through the choroid plexuses, the latter constitute another potential target to modulate seasonal reproduction. Therefore, we will also evaluate the impact of photoperiod on the transcriptome of this tissue. These data will provide insights into the molecular mechanisms of photoperiodism and offer potential avenues to develop innovative breeding strategies.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores