Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

CHROMOREPAIR

Financiado

Cerrado

Deciphering the role of chromatin remodelling in DNA damage repair

Our cells are faced with thousands of DNA lesions every day. Failure to repair such lesions can lead to genomic instability, cancer development or cell death. Repair of DNA damage, however, is complicated by the fact that genomic... ver más

31/12/2012

BIOMEDICALSCIENCES...

202K€

Presupuesto del proyecto: 202K€

Líder del proyecto

EREVNITIKO KENTRO VIOIATRIKON EPISTIMON ALEXA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2012-12-31 No tenemos la información de la convocatoria

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

BIOMEDICALSCIENCES RESEARCH...

0.00€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

PID2020-116003GB-I00 GENOMICA AVANZADA PARA EL ESTUDIO DE LA INTEGRIDAD DE CROMOS... 272K€ Cerrado

REMIND Epigenome maintenance in response to DNA damage 2M€ Cerrado

RecInRep Beyond double strand break repair specific mechanisms of ho... 175K€ Cerrado

aDDRess Joint Training and Research Program on Chromatin Dynamics an... 4M€ Cerrado

DAMAGE BYPASS Mechanistic analysis of DNA damage bypass in the context of... 2M€ Cerrado

BFU2010-16372 ROTURAS DE ADN ASOCIADAS A REPLICACION Y REPARACION POR RECO... 835K€ Cerrado

Líder del proyecto

EREVNITIKO KENTRO VIOIATRIKON EPISTIMON ALEXA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 202K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Our cells are faced with thousands of DNA lesions every day. Failure to repair such lesions can lead to genomic instability, cancer development or cell death. Repair of DNA damage, however, is complicated by the fact that genomic DNA is packaged, through histone and non-histone proteins, into a condensed structure called chromatin. Recently, an increasing interest on the impact of chromatin and the epigenetic changes that occur in DNA damage repair has emerged. Nevertheless, the functional interplay between damage-induced interference of transcription and modulation of chromatin to allow accessibility of DNA lesions by the repair machineries is still an enigma. Here, I propose biochemical and genetic approaches complemented with advanced proteomic and genome wide technologies to i) isolate and characterise the chromatin remodelling factors that functionally interact with damage arrested RNA Polymerase II/repair complexes in response to genotoxic stress. Focus will be on potential differences in the composition of protein complexes and their posttranslational modifications in normal human cells and in patient-derived repair deficient cells. ii) To decode the epigenetic changes that occur in response to DNA damage at genome wide level and in the vicinity of transcription blocking DNA lesions. iii) To elucidate the role of key repair and chromatin factors on transcription-mediated DNA damage response and study their interplay with damage signaling proteins (such as protein kinases, ubiquitin ligases, and histone methylases/acetyltransferases). These studies are expected to increase our understanding on the impact of chromatin function-structure and the histone modifications that occur upon genotoxic stress and change transiently the plasticity of chromatin structure, linking persistent damage in active genes to repair, cell cycle arrest or apoptosis in mammalian cells. In addition, this knowledge may lead to the identification of targets for therapeutic intervention.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores