Hola,
¿eres nuevo aquí?

Registrate y conecta tu empresa con financiación pública, partners y proyectos.

Stem2MorphoMap

Financiado

Deciphering the interplay between stem cell differentiation and stem cell dynami...

Deciphering the interplay between stem cell differentiation and stem cell dynamics in branching morphogenesis Tissue development requires the orchestration of stem cell differentiation and morphogenesis, a process that is conspicuously observed in mammary gland (MG) branching. The MG develops from an embryonic bud of mammary stem cells (M... ver más

31/08/2027

INSTITUT CURIE FON...

196K€

Presupuesto del proyecto: 196K€

Líder del proyecto

INSTITUT CURIE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-04-25

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

HORIZON-MSCA-2023-PF-01-01: MSCA Postdoctoral Fellowships 2023

I+D

Cerrada hace 1 año

0% 100%

1 Participantes

INSTITUT CURIE FONDATION

195.91K€ | Lider

Proyectos interesantes

BFU2015-71244-ERC ESTUDIO DE LA POLARIDAD PLANAR EN LA TUBULOGENESIS EPITELIAL... 60K€ Cerrado

BFU2012-35892 DESCIFRANDO LAS FUNCIONES Y ONTOGENIA DE LAS CELULAS MADRE/... 138K€ Cerrado

BFU2010-19656 FORMACION DEL EJE EMBRIONARIO EN UN SISTEMA REGULATIVO CONTR... 145K€ Cerrado

PID2019-105609GB-I00 PROCESOS DE DISTRIBUCION ASIMETRICA ASOCIADOS A LA HERENCIA... 242K€ Cerrado

BES-2013-065514 DESCIFRANDO LAS FUNCIONES Y ONTOGENIA DE LAS CELULAS MADRE/... 84K€ Cerrado

SAF2010-15450 DETERMINACION DEL DESTINO HEMATOPOYETICO EN EL EMBRION DE RA... 311K€ Cerrado

Últimas noticias

29-11-2024: IDAE En las últimas 48 horas el Organismo IDAE ha otorgado 4 concesiones

29-11-2024: ECE En las últimas 48 horas el Organismo ECE ha otorgado 2 concesiones

29-11-2024: CMVAMADRID En las últimas 48 horas el Organismo CMVAMADRID ha otorgado 37 concesiones

Duración del proyecto: 40 meses Fecha Inicio: 2024-04-25
Fecha Fin: 2027-08-31

Líder del proyecto

INSTITUT CURIE

TRL 4-5

Presupuesto del proyecto 196K€

Descripción del proyecto Tissue development requires the orchestration of stem cell differentiation and morphogenesis, a process that is conspicuously observed in mammary gland (MG) branching. The MG develops from an embryonic bud of mammary stem cells (MaSCs). Although these stem cells are initially bipotent, giving rise to the outer (basal) and inner (luminal) layers of the adult gland, they become lineage restricted very early in embryogenesis, at around the time of the onset of branching morphogenesis. The timing of lineage restriction coincides with the differential expression of cell polarity and cell adhesion transcripts. Branching morphogenesis then relies on differential cell division, as well as cell rearrangements and migration, but the mechanisms regulating this process in the embryo remain poorly understood. Based on these observations, we postulate that basal-biased and luminal-biased MaSCs have distinct molecular features during branching morphogenesis. We therefore propose to functionally link the signaling pathways involved in restriction of stem cell potency to the cellular dynamics that ensure branching. To this end, we will characterize the dynamic behaviour of individually labeled MaSCs during the growth of embryonic MG explants and assess their fate, creating a complete fate-behavior map of MG development. Through genetic manipulation, we will probe how cell adhesion, migration, and division impact on lineage specification and tissue growth. Simultaneously, we will skew stem cell differentiation trajectories and assess their influence on cell behavior and organ shape. The outcomes of this project will provide novel insights into the coordinated developmental programs governing stem cell fate and morphogenetic events, both essential to tissue formation. Moreover, they might uncover potential connections to cancer, where differentiatiom and cell polarity play pivotal roles.

Conecta tu I+D

Entra hoy

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores