LC-FMRI
Financiado
Deciphering the effects of locus coeruleus activity on whole brain dynamics and...
Deciphering the effects of locus coeruleus activity on whole brain dynamics and neurovascular coupling
Locus coeruleus (LC) regulates vital autonomous and cognitive functions and has recently gained interest as a clinical target in neurodegenerative and psychiatric disorders. Previous studies have investigated the effect of LC acti...
Locus coeruleus (LC) regulates vital autonomous and cognitive functions and has recently gained interest as a clinical target in neurodegenerative and psychiatric disorders. Previous studies have investigated the effect of LC activity on small groups of neurons and on endpoint behavior. However, LC’s widespread connections and broad downstream effects make a systems-level approach imperative for comprehensively understanding LC function. In LC-FMRI, we will perform highly specific optogenetic LC stimulation in mice and assess whole-brain responses and functional network reconfiguration using ultra-high field functional magnetic resonance imaging (fMRI). To decipher neural, astrocytic and vascular contributions to LC-induced fMRI responses, we will acquire simultaneous optical calcium recordings during fMRI. Experiments will be performed in awake mice to circumvent confounding effects of anesthesia on LC function. Finally, we will investigate how LC stimulation affects whole-brain dynamics and neurovascular coupling in the context of sensory processing. Our project will lay the foundation for studying how LC modulates whole-brain dynamics in health and disease using fMRI, with high potential for translation to human applications.
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Duración del proyecto: 28 meses
Fecha Inicio: 2019-04-24
Fecha Fin: 2021-08-31
Fecha Fin: 2021-08-31
Línea de financiación: concedida
El organismo H2020 notifico la concesión del proyecto el día 2021-08-31
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
WF-01-2018:
Widening Fellowships
Cerrada
hace 6 años
Presupuesto
El presupuesto total del proyecto asciende a
148K€
Líder del proyecto
FUNDACAO D. ANNA DE SOMMER CHAMPALIMAUD E DR....
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5
421.92K€ |
Participante