Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

BoneImaging

Financiado

Cerrado

Cryo analytical microscopy of cell mediated mineralization in models of bone dis...

Cryo analytical microscopy of cell mediated mineralization in models of bone disease The bone mineralization process is crucial in maintaining the mechanical integrity of bone, from the time of its development to its constant remodeling throughout life. The process of pathologic mineralization and bone remodeling... ver más

31/05/2023

KINGS COLLEGE LOND...

213K€

Presupuesto del proyecto: 213K€

Líder del proyecto

KINGS COLLEGE LONDON No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2023-05-31

MSCA-IF-2019: Individual Fellowships

I+D

Cerrada hace 5 años

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

KINGS COLLEGE LONDON

212.93K€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

DYNAMIN Deciphering collagen mineralization process by dynamic imagi... 188K€ Cerrado

SUPERMIN Correlative Super Resolution Imaging of the Collagen Mineral... 166K€ Cerrado

BOOST Biomimetic trick to re balance Osteblast Osteoclast loop in... 2M€ Cerrado

BoneImplant Monitoring bone healing around endosseous implants from mul... 2M€ Cerrado

CGL2011-25906 FORMACION DE HUESO MEDULAR Y CASCARA DE HUEVO COMO MODELO DE... 87K€ Cerrado

DPI2014-58233-P MODELOS DE COMPORTAMIENTO DEL TEJIDO OSEO INMADURO EN EL CAL... 169K€ Cerrado

Duración del proyecto: 37 meses Fecha Inicio: 2020-04-21
Fecha Fin: 2023-05-31

Líder del proyecto

KINGS COLLEGE LONDON No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 213K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The bone mineralization process is crucial in maintaining the mechanical integrity of bone, from the time of its development to its constant remodeling throughout life. The process of pathologic mineralization and bone remodeling and how cells control these processes, is very poorly understood in vivo. By characterizing unique animal models of bone pathologies, spanning both lack and increase of bone, this project will elucidate the process of cell-regulated mineralization during endochondral ossification, the mineralization process that occurs during growth of long bones, and also during adult remodeling. We will also investigate how a defect in mineralization affects the mineral content, composition and organization of the collagen fibrils and mineral in pathological bones. We will first map healthy (wildtype) mineralization, focusing on the cell regulated mineralization, mineral composition and structure in bone and calcified cartilage. We will then investigate how the cell regulated mineralization alters in hypomineralized bone models, which have been reported as abnormalities of skeletal development. Finally, we will study the bone remodeling in under and over producing bones in leukemia and parathyroid hormone (PTH) treated animal models. To address these problems, this work will combine multiscale, state of the art imaging and analysis techniques from dynamic live animal imaging (cellular level) to spatially resolved nanoscale (mineral and collagen fibrils) analytical techniques to characterize the processes by which bone mineralizes, remodels and also any alterations in these processes between healthy and pathologic tissues. Insight into skeletal cellular mineralization mechanisms in pathologic tissues could guide tissue engineering approaches for restoring bone and help to identify targeted treatments.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores