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SynHet

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Convergent and Efficient Synthesis of Novel Heteroaromatics

Cycloaddition reactions are extremely potent methods to form complex heterocycles. However, [3+2]-cycloadditions across alkynes are generally ineffective for the formation of 1,3-azoles which are key constituents of natural produc... ver más

20/01/2015

UoB

209K€

Presupuesto del proyecto: 209K€

Líder del proyecto

THE UNIVERSITY OF BIRMINGHAM No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2015-01-20 No tenemos la información de la convocatoria

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1 Participantes

UoB

0.00€ | Lider

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Líder del proyecto

THE UNIVERSITY OF BIRMINGHAM No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 209K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Cycloaddition reactions are extremely potent methods to form complex heterocycles. However, [3+2]-cycloadditions across alkynes are generally ineffective for the formation of 1,3-azoles which are key constituents of natural products, pharmaceuticals and materials. This project aims to establish a convergent and readily applicable gold-catalysed formal [3+2]-cycloaddition strategy to prepare diverse highly-substituted 1,3-azoles and related heteroaromatic structures. Reaction discovery and optimization will be followed by a detailed study of the substrate scope which will include the preparation of bioactive materials to demonstrate the efficacy of the proposed methodology to the synthetic community. The second major strand of the project will exploit the ability of this methodology to provide expedient access to functional materials, in the form of chiral aminooxazoles as the basis of organocatalyst systems. Transfer of the fellow’s prior expertise and knowledge of system design and reaction application in organocatalysis will be central to the development, study and application of this potentially privileged scaffold at the core of a range of organocatalyst families. The modular and convergent method of the oxazole synthesis will facilitate both major and fine tuning of the catalysts function in single point, dual point and triple point activation, across nucleophilic catalysis, H-bond activation, and secondary amine catalysis for iminium and enamine based processes. As well as the research impact and added value to the project from knowledge transfer, outreach activities across several layers of the population will be performed. An accessible resource will be prepared for scientists; general public knowledge and appreciation of chemistry will be enhanced, and the enthusiasm for science in the next generation of students and potential scientists will be encouraged.

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