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evolSingleCellGRN

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Constraint Adaptation and Heterogeneity Genomic and single cell approaches to...

Constraint Adaptation and Heterogeneity Genomic and single cell approaches to understanding the evolution of developmental gene regulatory networks Cell types in development arise from precise patterns of gene expression driven by differential usage of DNA regulatory elements. Mutations affecting these elements, or proteins binding them, are major contributors to disease and... ver más

31/01/2024

UBER

1M€

Presupuesto del proyecto: 1M€

Líder del proyecto

HUMBOLDTUNIVERSITAET ZU BERLIN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2024-01-31

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

ERC-2018-STG: ERC Starting Grant

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2 Participantes

UBER

1.50M€ | Lider

SOLUCIONES ELECTRICAS DE GAL...

438.68K€ | Participante

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Duración del proyecto: 60 meses Fecha Inicio: 2019-01-15
Fecha Fin: 2024-01-31

Líder del proyecto

HUMBOLDTUNIVERSITAET ZU BERLIN

TRL 4-5

Presupuesto del proyecto 1M€

Descripción del proyecto Cell types in development arise from precise patterns of gene expression driven by differential usage of DNA regulatory elements. Mutations affecting these elements, or proteins binding them, are major contributors to disease and underlie the evolution of new morphologies. To better understand these elements and how they evolve, I introduce a set of single-cell RNA and ATAC-Seq sequencing technologies that: A) Identify tissue-specific regulatory elements and expression profiles by interrogating individual cells, B) Allow for a precise read-out of developmental responses to mutation and perturbation, including cell-fate re-specification, C) Lead to the development of a regulatory-information based concept of homology that will be used to understand developmental evolution. The research makes use of sea urchins. The well-annotated sea urchin regulatory network, a detailed understanding of inductive interactions in early development, and an active body of evolutionary research justify this choice. Using single-cell ATAC-Seq and a new method for resolving single-cell, nascent transcripts, I will build a detailed atlas of sea urchin development and use this atlas to understand how regulatory landscapes change during specification and how they evolve between closely related species. I will also investigate, at single-cell resolution, how larval skeletal cells are regenerated following the loss of a cell lineage that mirrors euechinoid evolution. To better understand the origins of cell types in sea urchins, I will characterize embryos of the cnidarian Nematostella, using shared regulatory sites to define cell types which I will compare to urchins and my previous work in Drosophila. The work will generate single-cell methods for non-traditional model systems and help to resolve the processes by which, and the paths along which, development evolves.

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