Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

METABOLISMCONNECT

Financiado

Cerrado

Can metabolic states induced by diabetes and obesity promote cancer?

Continuous research on cancer has unraveled genetic alterations and subsequently signal transduction pathways changed in a cancer cell, thereby it emerged that many of the genetic factors commonly altered in cancer cells often tar... ver más

30/09/2017

VLAAMS INSTITUUT...

100K€

Presupuesto del proyecto: 100K€

Líder del proyecto

VIB VZW No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2017-09-30 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

VLAAMS INSTITUUT BIOTECHNOL...

0.00€ | Lider

Proyectos interesantes

SAF2016-81975-REDT

Medical Technol...

Data Science

20K€ Cerrado

RED2018-102379-T

Medical Technol...

Data Science

21K€ Cerrado

CNS2023-144419

Medical Technol...

Data Science

200K€ Cerrado

PancObese

Medical Technol...

Data Science

3M€ Cerrado

NoMePaCa

Medical Technol...

Data Science

2M€ Cerrado

OPEDGP

Medical Technol...

Data Science

200K€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Líder del proyecto

VIB VZW No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 100K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Continuous research on cancer has unraveled genetic alterations and subsequently signal transduction pathways changed in a cancer cell, thereby it emerged that many of the genetic factors commonly altered in cancer cells often target metabolic genes. An altered metabolism allows cancer cells to sustain their proliferative needs. Yet, whether altered metabolic fluxes and metabolite concentrations, which define the metabolic state of a cell, are only a consequence or can be a cause of cancer is a major question in the field. The hypothesis that certain metabolic states can precondition a cell for cancer is supported by epidemiological studies showing that patients suffering from diabetes or obesity have an increased risk to develop cancer and an increased cancer mortality rate. We propose to elucidate whether certain metabolic states promote liver cancer, which is in 30% of the cases associated with diabetes and obesity. We will measure metabolite concentrations and metabolic fluxes in tumorigenic versus non-malignant liver cells in vitro, to systematically identify metabolic states that are sufficient to drive an oncogenic transformation in the liver. Subsequently, we will map them in vivo onto metabolic states quantified in a diet and carcinogen induced mouse model, with the final goal to unravel the causal link between the increased liver cancer risk and the metabolic syndrome. Elucidating this metabolic interface will provide a mechanistic understanding of tumor initiating events in patients suffering from the metabolic syndrome. It will subsequently lead to new therapeutic strategies to prevent increased tumor events and cancer driven mortality rates in such patients.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores