Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

BARRIER BREAK

Financiado

Cerrado

Breaking the barrier How inflammation spreads from skin to joint

Physical barriers of the body and their immunological dysregulation are connected to a variety of inflammatory diseases and therefore an emerging area of interest in medicine. The gut and its microbiome gained center stage, wherea... ver más

31/12/2024

Universitätsklinik...

1M€

Presupuesto del proyecto: 1M€

Líder del proyecto

UNIVERSITATSKLINIKUM ERLANGEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2024-12-31

ERC-2019-STG: ERC Starting Grant

I+D

Cerrada hace 6 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

Universitätsklinikum Erlange...

1.49M€ | Lider

ADVANCELL ADVANCED IN VITRO...

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

MaRiA Microbiota and Resolvins in Arthritis 195K€ Cerrado

CD4INEAR Defining the cellular interactions that control the retentio... 100K€ Cerrado

RYC-2017-23437 Mecanismos moleculares implicados en el desarrollo de compli... 309K€ Cerrado

INSPIRE IN depth SPatiotemporal dissection of autoimmunity induced I... 2M€ Cerrado

MIAMI Monitoring innate immunity in arthritis and mucosal inflamma... 7M€ Cerrado

REpAIR Spatio Temporal Regulation of Inflammation and Tissue Regene... 2M€ Cerrado

Duración del proyecto: 60 meses Fecha Inicio: 2019-12-03
Fecha Fin: 2024-12-31

Líder del proyecto

UNIVERSITATSKLINIKUM ERLANGEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 1M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Physical barriers of the body and their immunological dysregulation are connected to a variety of inflammatory diseases and therefore an emerging area of interest in medicine. The gut and its microbiome gained center stage, whereas the skin as large primary immunological barrier to the environment is still less appreciated. Psoriatic arthritis (PsA) is a prototypic inflammatory disease which usually starts with skin lesions, before spreading to the musculoskeletal regions. To date, it is still obscure why the inflammatory process in some patients with psoriasis is restrained to the skin, whereas in other patients it extends to tendons and joints. Moreover, disease spreading to the joints associates with local tissue remodelling as evidenced by new bone formation at the insertion site of tendons into the bones. The molecular and cellular regulation of this skin-joint axis leading to development of PsA is still unclear but essential to understand organ communication in inflammatory diseases, the identification of potential biomarkers for early recognition of the disease and the development of preventive treatments. We will take advantage of a new model resembling PsA, which was established in our lab, with the aim of (1) studying disease spreading from the skin to musculoskeletal regions, (2) deciphering the molecular mechanisms that lead to uncontrolled local tissue remodeling, and finally (3) testing a new translational approach to prevent spreading of inflammation and tissue remodelling. We plan to adopt cutting-edge techniques to achieve our goals, which in turn will contribute to a better knowledge of the connection between epithelial surfaces and inflammation.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores