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SYSBIOPRO

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Bioproduction of pharmaceutically important iridoids systems biology based appr...

Bioproduction of pharmaceutically important iridoids systems biology based approach Plant in vitro technologies have been known for more than century. During this time, plant cell, tissue and organ cultures have become increasingly attractive and cost-effective alternatives to classical approaches for the mass pr... ver más

23/03/2012

ULEI

128K€

Presupuesto del proyecto: 128K€

Líder del proyecto

UNIVERSITEIT LEIDEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2012-03-23 No tenemos la información de la convocatoria

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

ULEI

0.00€ | Lider

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Líder del proyecto

UNIVERSITEIT LEIDEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 128K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Plant in vitro technologies have been known for more than century. During this time, plant cell, tissue and organ cultures have become increasingly attractive and cost-effective alternatives to classical approaches for the mass production of plant metabolites. Furthermore, plant in vitro systems are the only economically feasible way of producing some high-value metabolites from rare and/or threatened plants. The progress in this field has resulted in the mass production of several important metabolites, such as taxol (paclitaxel), shikonin and berberine by different companies. However, for their production several problems had to be overcome, mainly connected with their cultivation in vitro and high sensitivity to different stress factors/conditions. Today in the postgenomic era, new functional genomic tools (transcriptomics and proteomics), enabling comprehensive investigations of biological systems, are continuously further developing and are gradually being implemented in the field of plant secondary metabolism. The latest of the omics is metabolomics, which is now combined with the other omics and such a holistic functional genomic approach forms systems biology, in which the synergism of this powerful combination opens novel avenues to fully explore the total biochemical machinery of plants. The general objective of the scientific project is to evaluate the systems biology based approach for bioproduction of pharmaceutically important iridoids from difficult-to-access and endemic Bulgarian plant species. This includes transcriptomic analyses, metabolomics and assessment of biological activities. The metabolic engineering aspects will be also covered through gene/multigene transformations. The project will finally seek for development of technology platform for iridoids production in the green cell factory.

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