Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

GELVESICLE

Financiado

Cerrado

Biophysical principles of cellular morphogenesis

Living cells are endowed with structure and mechanical stability by an intricate elastic network of protein filaments known as the cytoskeleton. These filaments are stiff on the scale of the cell and thus readily deform the cell m... ver más

31/07/2011

NWO-I

161K€

Presupuesto del proyecto: 161K€

Líder del proyecto

STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZ... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2011-07-31 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

NWO-I

0.00€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

LeukocyteForces Cytoskeletal force generation and force transduction of migr... 1M€ Cerrado

COMPNET Dynamics and Self organisation in Complex Cytoskeletal Netwo... 1M€ Cerrado

BFU2011-22859 PAPEL DE LA PROTEINA 4.1 EN LA ORGANIZACION Y LA DINAMICA DE... 104K€ Cerrado

MEMBRANESACTIN Membrane triggered actin polymerisation molecular mechanism... 2M€ Cerrado

CytoskeletonCoupling Active actin microtubule crosstalk in reconstituted systems 183K€ Cerrado

ActinID A molecular atlas of Actin filament IDentities in the cell m... 1M€ Cerrado

Líder del proyecto

STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZ... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 161K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Living cells are endowed with structure and mechanical stability by an intricate elastic network of protein filaments known as the cytoskeleton. These filaments are stiff on the scale of the cell and thus readily deform the cell membrane, while simultaneously being affected configurationally by spatial confinement. The coupled morphogenesis of cytoskeleton and membrane ultimately appears as dynamic rearrangements that drive physiological processes such as cell migration or division. I strive to unravel biophysical principles of cell morphogenesis. To this end, I propose to construct biomimetic cell models by confining actin biopolymer gels to cell-sized lipid vesicles mimicking cellular confinement. I will systematically investigate the interplay between entropy-driven organization, and that induced by cross-linker proteins which connect actin filaments, or motor proteins which actively slide them. A key innovation lies in the bottom-up approach of gradually increasing system complexity to eventually achieve a model which is far more realistic than existing assays. The system permits quantitative measurements of network and membrane shape (using fluorescence microscopy) and of local and global mechanical properties as well as active driving (using innovative particle tracking microrheology). This will allow me testing and development of new theoretical models. The proposed project promises to significantly advance our understanding of how cells orchestrate their shape and movements, and to foster novel medical treatments of diseases related to malfunctions of the cytoskeleton. Simultaneously, it addresses exciting physical questions raised by the unusual properties of cells, such as self-organization of non-equilibrium soft matter and material properties of polymer-membrane composites. If we can identify physical design principles of cells we can eventually harness these to create novel functional and smart materials based on bio(-inspired) molecules.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores