Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

BioMPCat

Financiado

Cerrado

Bioorthogonal Metal Peptide Catalysis

In recent years, the development of bioorthogonal reactions has had a profound impact on several research areas such as imaging, drug development, biochemistry, and biotechnology. However, further advances in this topic are hinder... ver más

28/02/2019

ETH Zürich

175K€

Presupuesto del proyecto: 175K€

Líder del proyecto

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH No se ha especificado una descripción o un objeto social para esta compañía.

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2019-02-28

MSCA-IF-2016: Individual Fellowships

I+D

Cerrada hace 8 años

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

ETH Zürich

175.42K€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

BIOINCMED Bioinorganic Chemistry for the Design of New Medicines 2M€ Cerrado

CTQ2012-31341 HERRAMIENTAS QUIMICAS NO CLASICAS DIRIGIDAS AL ADN: METALOPE... 98K€ Cerrado

PERBIOIMAGE Exploring pericyclic reactions for bioorthogonal imaging of... 100K€ Cerrado

BES-2017-080360 QUIMICA SUPRAMOLECULAR Y DINAMICA DE PEPTIDOS CICLICOS PARA... 93K€ Cerrado

SAF2010-20822-C02-01 HERRAMIENTAS Y ESTRATEGIAS SINTETICAS PARA LA PREPARACION DE... 393K€ Cerrado

PhotoChemBio Photoredox catalysis as a tool for the site specific labelli... 189K€ Cerrado

Duración del proyecto: 24 meses Fecha Inicio: 2017-02-20
Fecha Fin: 2019-02-28

Líder del proyecto

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH No se ha especificado una descripción o un objeto social para esta compañía.

Presupuesto del proyecto 175K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto In recent years, the development of bioorthogonal reactions has had a profound impact on several research areas such as imaging, drug development, biochemistry, and biotechnology. However, further advances in this topic are hindered by the limited number of biocompatible chemical transformations and by their rather modest reaction rate. BioMPCat (Bioorthogonal Metal-Peptide Catalysis) aims at overcoming the current limitations by establishing metal-peptide complexes as a novel and powerful class of bioorthogonal catalysts capable of promoting unprecedented transformations with remarkable efficiency under physiological conditions. Naturally occurring peptides are ideally suited ligands for metals and, due to the inherent large structural and functional diversity, the chemical properties of their metal-complexes can be tuned to display optimal catalytic features: reactivity, selectivity, stability, and biocompatibility. Using simple and rationally designed combinatorial assays, the BioMPCat project will allow the identification of lead catalysts structures for biomolecules ligations as well as for site-selective cleavage of native proteins. The novel catalytic concepts will be established by: (1) identifying a non-toxic and highly effective Cu-peptide catalyst for the alkyne-azide cycloaddition reaction, which could render such important transformation compatible with the cellular environment; (2) developing a general approach to site-selective cleavage of native proteins based on the identification of a hydrolytically-active Zn-peptide complex. The research proposed herein will allow unprecedented investigations at the interface between chemistry and biology: new perspectives in biochemistry and cell biology will be opened, as well as novel avenues in medicinal chemistry and therapeutics.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores