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BIOSTASIS

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BIOlogical SignaTures of AnhydrobioSIS via comparative transcriptomics on diffe...

BIOlogical SignaTures of AnhydrobioSIS via comparative transcriptomics on different evolutionary lineages within tardigrades The current proposal revolves around the dehydration induced state, anhydrobiosis - a survival strategy found among a range of life-forms in face of severe desiccation. Anhydrobiosis is defined by a reversible shut-down of metabol... ver más

31/01/2020

UCPH

200K€

Presupuesto del proyecto: 200K€

Líder del proyecto

KOBENHAVNS UNIVERSITET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2020-01-31

MSCA-IF-2016: Individual Fellowships

I+D

Cerrada hace 8 años

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No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

UCPH

200.19K€ | Lider

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Duración del proyecto: 34 meses Fecha Inicio: 2017-03-17
Fecha Fin: 2020-01-31

Líder del proyecto

KOBENHAVNS UNIVERSITET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 200K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The current proposal revolves around the dehydration induced state, anhydrobiosis - a survival strategy found among a range of life-forms in face of severe desiccation. Anhydrobiosis is defined by a reversible shut-down of metabolism (biostasis) and it seems to involve adaptations at all levels of organismic organization. The current proposal uses tardigrades as a model to gain novel insight into molecular signatures underlying this unique biological phenomenon. Several molecules have been implicated in the anhydrobiotic mechanism; however, so far studies have been returning contradictory results with respect to the differential expression of genes in pre- and post-anhydrobiotic phases. Interestingly, our preliminary, unpublished data from Møbjerg lab suggest that there could be lineage specific strategies to anhydrobiosis. Consequently, I will use transcriptome sequencing (RNAseq) and ddPCR to reveal key-player genes and characterize functional pathways involved in i) different stages of anhydrobiosis of single tardigrade species and ii) between different evolutionary lineages within the phylum. The mentioned methods constitute the most important training element of my project. The overall goal of the proposal is to determine potential gene expression signatures for anhydrobiosis establishing a transcription profile that is i) characteristic of a particular physiological state and ii) that could possibly reflect the phylogenetic position of a taxon. My previous extensive experience on phylogenetic and molecular dating methods will, in this respect, be utilized to estimate the chronology of the possible diversification of anhydrobiosis within evolutionary lineages. My research will be conducted at the Møbjerg lab, which represents one of the world’s leading groups in the field of tardigrade biology. The group is situated at the Department of Biology, University Copenhagen, which is a superbly equipped institution with a high international profile.

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