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BiFOLDOME

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BiFoldome: Homo- and Hetero-typic Interactions in Assembled Foldomes

Self-assembly is a fundamental foundation of life, but what about co-assembly? The main goal of BiFOLDOME is to decipher co-assembly to understand self-assembly. Amyloids were assumed to be assembled by one type of protein,... ver más

31/10/2027

CSIC

1M€

Presupuesto del proyecto: 1M€

Líder del proyecto

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 2-3 | 552M€

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-08-25

ERC-2021-STG: ERC STARTING GRANTS Scope:Objectives

I+D

Cerrada hace 3 años

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No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

CSIC

1.50M€ | Lider

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Duración del proyecto: 62 meses Fecha Inicio: 2022-08-25
Fecha Fin: 2027-10-31

Líder del proyecto

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 2-3 | 552M€

Presupuesto del proyecto 1M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Self-assembly is a fundamental foundation of life, but what about co-assembly? The main goal of BiFOLDOME is to decipher co-assembly to understand self-assembly. Amyloids were assumed to be assembled by one type of protein, but our recent elucidation of the first 1:1 hetero-amyloid structure (the RIPK1-RIPK3 necrosome core) suggests that amyloids composed of two distinct proteins playing key roles in health and disease may be common. In fact, a viral protein (M45) can displace one partner (RIPK1) to form a distinct 1:1 hetero-amyloid (M45-RIPK3). Taking a leaf from the viral playbook, this means that for a given self-assembling sequence there may be a mating sequence driving the preferential 1:1 co-assembly of the two. Thus, understanding what drives the preferential formation of co-assembled forms over conventional self-assembled species will afford an entirely new vision on assembly processes transversal to all fields of knowledge. BiFOLDOME is organized around three different levels of complexity: (1) characterizing the formation, structure and energetics of representative paradigms of 1:1 co-assembled amyloids using solution and solid-state NMR spectroscopies, and energy calculations, featuring novel technical innovations that we will develop. This will provide the basis for self-assembly by delivering a firm understanding of co-assembly. (2) Applying the fundamental knowledge from (1) to the manipulation of self-assembled, disease-associated proteins using the powerful concept of 1:1 co-assembly. (3) Going beyond the state of the art by developing a new methodology to study the assembly of biomolecular condensates. The approach, which I call optoNMR, will enable controlled, light-triggered self- and co-assembly of proteins within the NMR tube, opening new avenues to discern between alternative hypotheses for condensate formation and hardening in real-time and at high resolution, or for sensitive detection using hyperpolarization schemes.

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