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AttoDNA

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AttoDNA how electronic motions affect the photostability of the genomic materia...

AttoDNA how electronic motions affect the photostability of the genomic material AttoDNA considers the early (attosecond to few-femtosecond) events following photo-excitation/ionisation in DNA/RNA canonical and non-canonical nucleobases for the first time. This involves the electronic movement before the onset... ver más

29/02/2020

IMPERIAL COLLEGE O...

183K€

Presupuesto del proyecto: 183K€

Líder del proyecto

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND ME... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2020-02-29

MSCA-IF-2016: Individual Fellowships

I+D

Cerrada hace 8 años

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No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

IMPERIAL COLLEGE OF SCIENCE...

183.45K€ | Lider

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Duración del proyecto: 35 meses Fecha Inicio: 2017-03-17
Fecha Fin: 2020-02-29

Líder del proyecto

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND ME... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 183K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto AttoDNA considers the early (attosecond to few-femtosecond) events following photo-excitation/ionisation in DNA/RNA canonical and non-canonical nucleobases for the first time. This involves the electronic movement before the onset of nuclear dynamics, ascertaining the length in which this initial purely electronic motion extends in time and how it affects the ensuing nuclear dynamics and its outcome with regards to the photostability shown by the genomic material from a bottom-up approach. By monitoring the electronic and nuclear motions in canonical and non-canonical nucleobases, the way in which they couple can be elucidated and the specific motions contributing to photostability extracted from a novel standpoint. Photostability is one of the main properties thought to play a crucial role in the selection of the nucleobase monomers in prebiotic extreme UV exposure, by encoding the genome using the most suitable (photostable) building blocks as an elegant solution to aid in its photo-protective design and thus defend itself against the threat of photochemical damage. Beyond its intrinsic importance given its essential role towards preserving our genomic material, an in-depth knowledge of this outstanding property also provides a unique perspective on the events where these photo-protection mechanisms fail, namely the photo-damage instances, and in the subsequent repair mechanisms mediated by electron transfers as those put in place by enzymes and/or in specific non-invasive treatments like photodynamic therapies, the most widespread treatment for cancer. The project therefore aims at extending the foundations rationalising DNA's photostability by exploring the potential role of the electronic dynamics prior to the onset of nuclear dynamics for the first time and is expected to have a large impact in the fields of photochemistry and photobiology.

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