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STARLIGHT

Financiado

Cerrado

Steering attosecond electron dynamics in biomolecules with UV XUV LIGHT pulses

One of the challenges facing science is to understand the chemical origin of DNA damage-induced mutations. Upon exposure to UV light, DNA nucleobases become electronically excited. This process potentially favors mutagenic miscodi... ver más

31/12/2020

DESY

1M€

Presupuesto del proyecto: 1M€

Líder del proyecto

DEUTSCHES ELEKTRONENSYNCHROTRON DESY No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 3 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2020-12-31

ERC-StG-2014: ERC Starting Grant

I+D

Cerrada hace 10 años

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3 Participantes

DESY

812.50K€ | Lider

CEPSA COMERCIAL PETROLEO

403.90K€ | Participante

CNR

684.50K€ | Participante

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Duración del proyecto: 70 meses Fecha Inicio: 2015-02-06
Fecha Fin: 2020-12-31

Líder del proyecto

DEUTSCHES ELEKTRONENSYNCHROTRON DESY No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 1M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto One of the challenges facing science is to understand the chemical origin of DNA damage-induced mutations. Upon exposure to UV light, DNA nucleobases become electronically excited. This process potentially favors mutagenic miscoding of the DNA sequence. The main target of STARLIGHT is to study with unprecedented temporal resolution (few-femtoseconds/attoseconds) the electron dynamics occurring in UV photoexcited biomolecules. I will mainly consider aromatic complexes including DNA nucleobases (and ultimately DNA) with the aim of tracking in real time the electron dynamics preceding structural changes potentially leading to damage. The proposed research is based on a bottom-up approach: it allows one to understand the physical origin of a variety of light-driven processes occurring in more complex biological systems of crucial importance in photochemistry and photobiology, with tremendous prospects in phototherapy. Electron motion in molecules occurs on a temporal scale ranging from few femtoseconds down to attoseconds. Attosecond science is nowadays a well-established field and electron dynamics has been successfully studied in atoms and small molecules. The work recently conducted by the PI has demonstrated that this technology is mature and ready to be applied to more complex systems such as biomolecules. Electron dynamics will be resonantly activated in biomolecules by few-cycle UV pump pulses and subsequently probed by as-XUV pulses or few-fs-UV pulses. Through time-resolved measurements of the molecular photo-fragmentation, gas-phase spectroscopy will be used to elucidate the role of electrons in the photoreactivity of the molecule in a solvent-free environment. With the final goal of steering the electronic motion, circularly polarized UV pulses will be also used to induce electronic currents in cyclic biomolecules. These ring currents can be exploited to generate intense magnetic fields with promising applications in molecular electronics and quantum control.

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