Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

INVIVOPOL

Financiado

Cerrado

Assembly and host interactions of influenza virus polymerase in the living cell

Currently circulating highly pathogenic avian influenza virus strains (H5N1) could cause a devastating pandemic if they became transmissible between humans. Thus understanding of the mechanisms whereby influenza virus adapts from... ver más

31/12/2011

EMBL

150K€

Presupuesto del proyecto: 150K€

Líder del proyecto

EUROPEAN MOLECULAR BIOLOGY LABORATORY No se ha especificado una descripción o un objeto social para esta compañía.

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2011-12-31 No tenemos la información de la convocatoria

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

EMBL

0.00€ | Lider

Proyectos interesantes

Bat Flu

Medical Technol...

Applied Physics

2M€ Cerrado

BFU2011-25090

Medical Technol...

Applied Physics

142K€ Cerrado

AvINFLUENZA

Medical Technol...

Applied Physics

185K€ Cerrado

BFU2014-58929-R

Medical Technol...

Applied Physics

230K€ Cerrado

Influenza RNP

Medical Technol...

Applied Physics

185K€ Cerrado

VIRUS ENTRY

Medical Technol...

Applied Physics

4M€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Líder del proyecto

EUROPEAN MOLECULAR BIOLOGY LABORATORY No se ha especificado una descripción o un objeto social para esta compañía.

Presupuesto del proyecto 150K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Currently circulating highly pathogenic avian influenza virus strains (H5N1) could cause a devastating pandemic if they became transmissible between humans. Thus understanding of the mechanisms whereby influenza virus adapts from avian to mammalian hosts is of great significance. Recent studies have highlighted the importance for transmissibility of mutations in the viral polymerase - a trimeric complex possessing activities essential for transcription and replication of the viral RNA. The mechanism of polymerase assembly and the host factors involved are not clear yet, nor are the molecular functions affected by the mutations related to avian-to-mammal transmission. To clarify these and to complement the extensive studies of atomic resolution structure of the polymerase and its host-specific variants performed in the Host laboratory, we propose to investigate in living cells the intracellular trafficking, assembly and interactions with host cell factors of the human and avian variants of the polymerase subunits. State-of-the-art two-colour fluorescence cross-correlation spectroscopy (FCCS) and confocal microscopy techniques will be used to monitor these phenomena in a non-invasive way. The project is inter-disciplinary as it combines advanced cell biophysics with structural and molecular biology in order to address a very topical issue in virology. The results will contribute to understanding of the relationships between the atomic structure of influenza virus polymerase and its function in the infected cell. New insight into adaptation of the influenza virus replication machinery to mammalian hosts can be used to elaborate new strategies for development of anti-viral compounds targeting polymerase or its interactions with host cell factors. Pursuing this multidisciplinary project in a prestigious international environment and learning state-of-the-art techniques will provide the applicant an excellent training for a future independent research position

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores