Hola,
¿eres nuevo aquí?

Registrate y conecta tu empresa con financiación pública, partners y proyectos.

PhotoLanZyme

Financiado

Artificial Lanthanide Enzymes for Selective Photocatalysis: 'Enlightening' Meta...

Artificial Lanthanide Enzymes for Selective Photocatalysis: 'Enlightening' Metalloenzyme Design and Evolution Enzymes are efficient and selective biocatalysts. They are in high demand in chemical and pharmaceutical industry, as they facilitate more sustainable production processes. However, it remains challenging to develop novel enzymes... ver más

30/04/2027

TUM

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

TECHNISCHE UNIVERSITAET MUENCHEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-04-11

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

ERC-2021-STG: ERC STARTING GRANTS

I+D

Cerrada hace 3 años

0% 100% 100%

1 Participantes

TUM

1.50M€ | Lider

Proyectos interesantes

CTQ2016-78580-C2-2-R DESARROLLO DE NUEVOS SISTEMAS MOLECULARES Y SUPRAMOLECULARES... 97K€ Cerrado

CTQ2012-31063 SINTESIS DE CARBOHIDRATOS Y PROTEINAS UNIDOS A LANTANIDOS. N... 74K€ Cerrado

Co-ARMs Development of new-to-nature reactions under the concept of... 188K€ Cerrado

PGC2018-101737-B-I00 CATALISIS DE OXIDACION BIOINSPIRADA MEDIANTE DISEÑO RACIONAL... 242K€ Cerrado

PCI2018-092984 FABRICACION DE BIOCATALIZADORES HETEROGENEOS MULTIFUNCIONALE... 200K€ Cerrado

CTQ2010-17339 "DESCONSTRUCCION" DE BIGINELLI: CATALISIS ENANTIOSELECTIVA V... 109K€ Cerrado

Últimas noticias

02-12-2024: AGENCIA-VALENCIANA-D... En las últimas 48 horas el Organismo AGENCIA VALENCIANA D... ha otorgado 1 concesiones

02-12-2024: CDTI En las últimas 48 horas el Organismo CDTI ha otorgado 4 concesiones

01-12-2024: REDES En las últimas 48 horas el Organismo REDES ha otorgado 1337 concesiones

Duración del proyecto: 60 meses Fecha Inicio: 2022-04-11
Fecha Fin: 2027-04-30

Líder del proyecto

TECHNISCHE UNIVERSITAET MUENCHEN

TRL 4-5

Presupuesto del proyecto 2M€

Descripción del proyecto Enzymes are efficient and selective biocatalysts. They are in high demand in chemical and pharmaceutical industry, as they facilitate more sustainable production processes. However, it remains challenging to develop novel enzymes that catalyze reactions beyond nature's synthetic repertoire. To tackle this problem, I propose a fundamentally new approach that merges metal-dependent chemical photocatalysis with enzyme engineering. Photoexcitation is a powerful catalytic tool. It enables alternative modes of substrate activation by generating radical intermediates. Controlling these reactive species to confer regio- and stereoselectivity, however, is a major challenge in synthetic chemistry. The key idea of this proposal is thus to perform photocatalytic reactions inside the chiral environment of artificial metalloproteins, which can be optimized efficiently by directed evolution. My group recently established the formation of lanthanide-protein complexes from highly stable, computationally designed protein scaffolds. Based on this work, we now aim to engineer a photoenzymatic platform for synthetically valuable chemistry. The main goal is to implement and optimize lanthanide photocatalysis in these proteins to facilitate stereoselective C-H activation and C-C bond forming reactions. Moreover, a fundamental mechanistic understanding how such new photocatalytic function emerges in proteins will be crucial for enzyme engineering. To that end, I propose a strategy that mimics natural evolution in a two-step process. Starting from libraries of naive small proteins, a high-throughput screen will first identify lanthanide binders, which are then exposed to a selection system that couples the survival of a bacterial host to an enzymatic detoxification reaction. PhotoLanZyme will yield a new class of sustainable and stereoselective photobiocatalysts. The approach is transferable to other photoredox-active metals, emphasizing its broad potential for synthetic applications.

Conecta tu I+D

Entra hoy

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores