Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

PROTEIN PREDICTION

Financiado

Cerrado

Application of reduced space modeling and sparse experimental restraints to str...

Application of reduced space modeling and sparse experimental restraints to structure determination of proteins and protein assemblies The knowledge of protein structures is critical for understanding of molecular machinery, discovering metabolic pathways, rational drug design and many other aspects of life at the molecular level. The number of currently know pro... ver más

30/09/2011

UNIWARSAW

208K€

Presupuesto del proyecto: 208K€

Líder del proyecto

UNIWERSYTET WARSZAWSKI No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2011-09-30 No tenemos la información de la convocatoria

0% 100% 100%

Características del participante

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

UNIWARSAW

0.00€ | Lider

Proyectos interesantes

PTQ2020-011291

Software

Data Science

37K€ Cerrado

PROMOS

Data Science

Software

222K€ Cerrado

PID2020-116564GB-I00

Software

Data Science

248K€ Cerrado

IJC2020-045506-I

Data Science

Software

98K€ Cerrado

WeNMR

Software

Data Science

2M€ Cerrado

PID2020-115557GB-I00

Bioinformatics

Data Science

242K€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Líder del proyecto

UNIWERSYTET WARSZAWSKI No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 208K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The knowledge of protein structures is critical for understanding of molecular machinery, discovering metabolic pathways, rational drug design and many other aspects of life at the molecular level. The number of currently know protein sequences however greatly outnumber known protein structures. Moreover this gap is rapidly growing. Therefore in the past few decades a number of theoretical approaches have been proposed for computational prediction of protein structures. During this project a novel protocol for protein structure prediction will be developed. A new software will be written, tested and applied on a genomic scale. The approach will be based on novel methodological advances, developed during the project. Among the most important elements are: (i) Multiscale approach: during a modeling process it will be possible to switch between several levels of coarse-graining. Low resolution protein representation will be used for an extremely efficient conformational search. Promising regions of solutions space will be further explored by a more detailed and more accurate model. (ii) A new family of force fields will be designed for accurate calculation of protein's energy at each of levels of coarse-graining (i.e. a separate force field for each levels of coarse-graining). (iii) Novel Monte Carlo techniques will be applied and tuned for further speed-up of conformational sampling. Monte Carlo methods will be also applied at the stage of force field development. (iv) Experimental information obtained from SAXS, EM, NMR, mutagenesis and other techniques will be used to direct the search of the conformational space and to increase modeling accuracy. The novel protocol developed during this project allow for structure determination of proteins and protein-protein complexes in a high-throuput fashion. The method will be shared as a publicly available Internet service and tested on representative benchmarks, e.g. a small genome.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores