Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

CVM THERAPY

Financiado

Cerrado

Angiogenesis Research to Improve Therapies for Vascular Malformations

Congenital Vascular Malformations (CVM) are a group of diseases characterized by an inborn, localized defects of vascular morphogenesis. Occurring mainly on the face or other highly visible part of the body, the presence of CVM ca... ver más

14/03/2015

Sheba Research Fun...

100K€

Presupuesto del proyecto: 100K€

Líder del proyecto

MEDICAL RESEARCH INFRASTRUCTURE DEVELOPMENT A... No se ha especificado una descripción o un objeto social para esta compañía.

Fecha límite participación Sin fecha límite de participación.

Ver 2 Participantes

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2015-03-14 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

Sheba Research Fund

100.00K€ | Lider

MEDICAL RESEARCH INFRASTRUCT...

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

WNT VASCULAR REMODEL Molecular control of vascular remodelling A role for Wnt si... 173K€ Cerrado

CAPI ROLE OF CYCLOPHILIN A IN BONE MARROW VASCULAR PROGENITOR CEL... 100K€ Cerrado

ADAPT2FLOW Adaptive and maladaptive endothelial cell dynamics during bl... 148K€ Cerrado

SAF2017-83229-R FUNCIONES DE LAS MT-MMP DEPENDIENTES DE FLUJO VASCULAR EN CO... 218K€ Cerrado

ANGIOBONE Angiogenic growth specialization ageing and regeneration o... 2M€ Cerrado

EC metabolism Understanding the metabolism of endothelial cells underlying... 170K€ Cerrado

Líder del proyecto

MEDICAL RESEARCH INFRASTRUCTURE DEVELOPMENT A... No se ha especificado una descripción o un objeto social para esta compañía.

Presupuesto del proyecto 100K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Congenital Vascular Malformations (CVM) are a group of diseases characterized by an inborn, localized defects of vascular morphogenesis. Occurring mainly on the face or other highly visible part of the body, the presence of CVM can cause emotional and social problems. Moreover, some malformations are painful or even life-endangering. Current treatments do not achieve optimal or long-lasting results. Thus, there is a pressing need for therapies that are more effective for these disfiguring lesions. Currently, the cellular components of the CVM have not been isolated and analyzed, and there is no animal model for most CVM. One attractive treatment strategy is to induce transdifferentiation of the endothelial cells (ECs) of the lesion. Transdifferentiation is the reprogramming of one specialized cell type into another, without reversion to pluripotent cells. The goal of my research is to isolate and characterize the EC, the major cellular component of the vascular malformations in order to develop targeted therapy for these lesions. EC and pericytes will be isolated from CVM tissues. We will perform extensive mutational analysis and epigenetic profiling of these primary cells in order to identify any abnormalities in their developmental path. Also, using novel techniques derived from the stem cell field, I will aim at inducing transdifferentiation of the l EC by forced expression of transcription factor pools. My hypothesis is that reprogramming the EC lining the vasculature of the lesion to a mesenchymal phenotype will lead to obstruction of these vessels and cessation of blood flow, resulting in significant improvement. Importantly, insights gained from this research will have wide implications for the vascular biology field. Thus, this project is novel and innovative. Having both extensive research experience with the study of angiogenesis and clinical expertise in Dermatology, I’m well-suited for the conduction of this project.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores