Innovating Works

ANFIBIO

Financiado
AmplificatioN Free Identification of cancer and viral biomarkers via plasmonic n...
AmplificatioN Free Identification of cancer and viral biomarkers via plasmonic nanoparticles and liquid BIOpsy The detection of circulating disease biomarkers in bodily fluids, also known as liquid biopsy, has taken important strides toward the implementation of personalized medicine. However, it still suffers from low sensitivity and high... The detection of circulating disease biomarkers in bodily fluids, also known as liquid biopsy, has taken important strides toward the implementation of personalized medicine. However, it still suffers from low sensitivity and high costs, which render its clinical implementation not practical or affordable. In particular, the identification and quantification of oligonucleotide biomarkers is hampered by the need to employ long- and short-read sequencing tools that are expensive, require highly trained personnel, and are prone to error. Nonetheless, the recent clinical breakthroughs demonstrating the importance of detecting cancerous or viral biomarker to susceptibility, onset, and aggressiveness of the disease, motivate the need for further research that could render their detection simpler, cheaper, and thus more widely available. By leveraging the intrinsic amplification capability of surface enhanced Raman scattering (SERS), in ANFIBIO I will address the issues of low sensitivity and high costs by combining plasmonic nanoparticles synthesized ad hoc to maximize SERS signal amplification with direct SERS sensing and machine learning tools for the rapid analysis of the complex spectral responses obtained by screening bodily fluids for specific target biomarkers. I will focus in particular on prostate cancer (PCa) DNA and influenza A viral (IAV) RNA in blood, urine, and saliva, to quantify and correlate their amounts to those detected in tissues and cells. At completion, the proposed work will deliver a breakthrough sensing technology capable of detecting and quantifying cancerous and viral biomarkers in bodily fluids, with minimal sample pretreatment, no target amplification, and that uses SERS as novel and reliable transduction mechanism with distinct advantages over those currently employed. Furthermore, the fundamental insight garnered will likely assess the feasibility of using direct SERS sensing to develop beyond-third generation sequencing technologies. ver más
31/05/2026
POLITO
3M€
Perfil tecnológico estimado
Duración del proyecto: 72 meses Fecha Inicio: 2020-05-29
Fecha Fin: 2026-05-31

Línea de financiación: concedida

El organismo H2020 notifico la concesión del proyecto el día 2020-05-29
Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:
ERC-2019-COG: ERC Consolidator Grant
Cerrada hace 5 años
Presupuesto El presupuesto total del proyecto asciende a 3M€
Líder del proyecto
POLITECNICO DI TORINO No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico TRL 4-5