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FLEXINGPLEXIN

Financiado

A structure function analysis to discover how receptor conformations and interac...

A structure function analysis to discover how receptor conformations and interactions determine semaphorin neuropilin plexin signalling outputs. During the development of a multicellular organism cell guidance proteins interact with their cognate cell surface receptors to guide cells to their correct location. Such functions continue to be essential in the adult to maintai... ver más

30/09/2025

UOXF

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UN... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

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Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2020-04-24

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

ERC-2019-ADG: ERC Advanced Grant

I+D

Cerrada hace 5 años

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2 Participantes

UOXF

2.08M€ | Lider

PLATOS TRADICIONALES

606.08K€ | Participante

Últimas noticias

25-11-2024: ECE En las últimas 48 horas el Organismo ECE ha otorgado 52 concesiones

25-11-2024: CMVAMADRID En las últimas 48 horas el Organismo CMVAMADRID ha otorgado 1 concesiones

25-11-2024: FUNDACION-EOI En las últimas 48 horas el Organismo FUNDACION EOI ha otorgado 6 concesiones

Duración del proyecto: 65 meses Fecha Inicio: 2020-04-24
Fecha Fin: 2025-09-30

Presupuesto del proyecto 2M€

Descripción del proyecto During the development of a multicellular organism cell guidance proteins interact with their cognate cell surface receptors to guide cells to their correct location. Such functions continue to be essential in the adult to maintain tissue homeostasis. Semaphorins use plexins as their main receptors for signalling and the semaphorin and plexin families together constitute one of the largest and functionally diverse of the cell guidance systems in vertebrates. We have gained some insight into the architecture and interactions which trigger semaphorin-plexin signalling, but fundamental questions remain and some of the most puzzling, and of potential clinical importance, concern the mechanisms of action of the secreted class 3 semaphorins (Sema3s), and their (co-)receptors. Neuropilin co-receptors play pivotal roles for Sema3 function and have been implicated in context dependent switching of cell guidance signalling outputs. There is an urgent need for information on molecular mechanism to underpin the design and interpretation of studies into biological function and clinical pathology. To advance the field we will combine structural biology and cellular imaging based approaches with functional studies (in house and in collaboration). The research plan is sub-divided into three inter-related sections that aim to discover: 1. The structural determinants and mechanisms of action by which class 3 semaphorins exert differing effects on signalling. 2. The conformational state of the plexin ectodomain in different contexts and its contribution to signal outcome. 3. The mechanisms by which neuropilin binding can switch the outcomes of plexin signalling. Molecular level answers to the questions posed by semaphorin-neuropilin-plexin signalling will take us beyond the current state of the art, and impact on diverse disciplines, for example cellular immunology and developmental biology, as well as guiding the design of novel therapeutic agents.

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