NeuroSonoGene
Financiado
A sonogenetic brain-machine interface for neurosciences and visual restoration
Brain-machine interfaces are classically based on multi-electrode arrays. Optogenetics has revolutionized this ability to control neuronal activity through ectopic opsin expression but its application to large brains remains limit...
Brain-machine interfaces are classically based on multi-electrode arrays. Optogenetics has revolutionized this ability to control neuronal activity through ectopic opsin expression but its application to large brains remains limited because of tissue light absorption and scattering. Ultrasound waves have been proposed for remote neuromodulation, but this approach has remained restricted to low-frequency excitation, to prevent brain tissue overheating, at the expense of spatial resolution. The expression of mechanosensitive proteins in neurons has recently made it possible to achieve the ultrasound (US) activation of neurons at high US frequencies, an approach named “sonogenetic”. Using the MscL mechanosensitive ionic channel, we recently provided a first proof of concept in rodents that cortical neurons can be activated in vivo by ultrasounds at a high spatiotemporal resolution and low intensity. Here, we propose to develop an integrated sonogenetic strategy for distant activation/inhibition of neuronal networks by ultrasound waves in large primate brains. The project includes: 1) optimizing and diversifying the sonogenetics actuators for safe neuronal control 2) designing technologies for patterned ultrasound stimulations, 3) demonstrating efficacy and high spatiotemporal resolution of the sonogenetic approach in controlling the primate visual cortex. This project is based on a unique synergistic combination of expertise, with a synthetic biologist in ion channel engineering, a neurobiologist with expertise in vision, and a physicist with expertise in ultrasound technologies. These 3 PIs will be supported by an expert in AAV vector mediated delivery. The project outcomes will be a novel brain-machine interface for investigating neural circuit function even deep within large brains through contactless sonogenetics. This sonogenetic technology will open new avenues for treating neurological dysfunction such as restoring vision in blind patients.
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Duración del proyecto: 71 meses
Fecha Inicio: 2024-06-01
Fecha Fin: 2030-05-31
Fecha Fin: 2030-05-31
Línea de financiación: concedida
El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-06-01
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
ERC-2023-SyG:
ERC Synergy Grants
Cerrada
hace 1 año
Presupuesto
El presupuesto total del proyecto asciende a
8M€
Líder del proyecto
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHER...
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5