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EUROSKINGRAFT

Financiado

Cerrado

A novel generation of skin substitutes to clinically treat a broad spectrum of s...

A novel generation of skin substitutes to clinically treat a broad spectrum of severe skin defects Large full-thickness skin defects resulting from burns, soft tissue trauma, congenital giant nevi, tumour resection, and disease leading to skin necrosis, represent a significant and common clinical problem worldwide. This problem... ver más

30/09/2016

UZH

8M€

Presupuesto del proyecto: 8M€

Líder del proyecto

UNIVERSITAT ZURICH No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 8 Participantes

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2016-09-30 No tenemos la información de la convocatoria

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

8 Participantes

UZH

0.00€ | Lider

GABO:mi

N.D. | Participante

ARTTIC

N.D. | Participante

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Líder del proyecto

UNIVERSITAT ZURICH No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 8M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Large full-thickness skin defects resulting from burns, soft tissue trauma, congenital giant nevi, tumour resection, and disease leading to skin necrosis, represent a significant and common clinical problem worldwide. This problem is far from being solved. The main challenge encountered is that most autologous skin grafting techniques are based on transplanting split-thickness skin (the today’s gold standard). Split-thickness skin contains all of the epidermis, but only remnants of the dermis. This lack of dermal tissue, frequently leads to significant scarring. Consequently, a true dermal substitute is required, which instantly exerts the cell-instructive properties of a neo-dermis. The partners of EuroSkinGraft can now offer 2 dermal substitutes, Novomaix and denovoDerm, plus the dermo-epidermal skin substitute denovoSkin. The development of all 3 substitutes was significantly supported by the FP6-program (EuroSTEC). The envisaged clinical studies are aiming strictly at a one-step surgical procedure (instead of the common two-step procedure, using Integra Artificial Skin).This is to be reached with the following protocol: Clinical application of Novomaix 1. Experimental arm 1: split-thickness skin on Novomaix applied on full-thickness wounds 2. Reference arm 1: split-thickness skin applied directly on the wound bed Clinical application of denovoDerm 1. Experimental arm 1: split-thickness skin on denovoDerm applied on full-thickness wounds 2. Reference arm 1: split-thickness skin applied directly on the wound bed Clinical application of denovoSkin 1. Experimental arm 1: denovoSkin applied on full-thickness wounds 2. Reference arm 1: split-thickness skin applied directly on the wound bed The strength of this project lies in: the high degree to which real regenerative medicine is translated into the clinic, the innovative and highly functional character of the 3 products to be tested, the central contribution of the 3 SMEs, and the excellence of the 3 clinics.

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