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SkinTERM

Financiado

Cerrado

Skin Tissue Engineering and Regenerative Medicine From skin repair to regenerat...

Skin Tissue Engineering and Regenerative Medicine From skin repair to regeneration Transplantation of autologous split-thickness skin -the epidermis with a tiny layer of dermis- remains the golden standard for various skin wounds like burns and large trauma. This treatment, however, comes with a number of seriou... ver más

31/07/2025

RADBOUDUMC

3M€

Presupuesto del proyecto: 3M€

Líder del proyecto

STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRU... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 10 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2020-08-28

MSCA-ITN-2020: Innovative Training Networks

I+D

Cerrada hace 5 años

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

10 Participantes

RADBOUDUMC

531.24K€ | Lider

SELECCIO DESEURAS SL

436.93K€ | Participante

STICHTING AMSTERDAM UMC

265.62K€ | Participante

UZH

562.55K€ | Participante

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Duración del proyecto: 59 meses Fecha Inicio: 2020-08-28
Fecha Fin: 2025-07-31

Líder del proyecto

STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRU... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 3M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Transplantation of autologous split-thickness skin -the epidermis with a tiny layer of dermis- remains the golden standard for various skin wounds like burns and large trauma. This treatment, however, comes with a number of serious drawbacks, including pain, mobility-limiting contractures and disfiguring scars. The SkinTERM consortium will address wound healing in a completely different way, recapitulating (certain aspects of) skin embryonic development in adults, and aiming for regeneration rather than repair. Skin organogenesis will be induced by key elements taken from the extracellular matrix of foetal and non-scarring species and by employing (stem) cells from relevant cellular origins. The starting point for the study is the remarkable capability of early foetal skin and skin from the spiny mouse (Acomys) to heal perfectly without scars/ contraction and with appendices such as hair follicles. Novel biomaterials and skin substitutes will be developed and evaluated. In order to effectively embrace this new approach, the PhD students need to have knowledge in key elements of basic science, regenerative medicine and biomaterial sciences. As translation to medical devices and especially advanced therapy medicinal products is currently too limited, we will give the PhD students a solid theoretical and practical foundation on topics like regulatory affairs, GMP and GCP, as well as secondments in industry. Driven by both the enthusiasm to gain basic scientific insights and the need for efficacious and innovative therapies, the students will acquire expertise through cutting edge scientific projects and will be trained by leading experts in all required skills to further develop their scientific findings into real life-science products. The SkinTERM program will thus create a new generation of entrepreneurial, multidisciplinary and inter-sectorially trained scientists with excellent career perspectives in either academia, industry or government.

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