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COLMIN

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Cerrado

A Google Earth Approach to Understanding Collagen Mineralization

Collagen mineralization in bone is one of the most crucial processes in our body as it supplies the skeleton on which we depend for support and protection. Bone’s impressive mechanical properties arise from the hierarchical organi... ver más

30/04/2025

RADBOUDUMC

3M€

Presupuesto del proyecto: 3M€

Líder del proyecto

STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRU... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

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Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2018-05-24

ERC-2017-ADG: ERC Advanced Grant

I+D

Cerrada hace 7 años

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

4 Participantes

RADBOUDUMC

3.28M€ | Lider

INSTALACIONES INABENSA

1.09M€ | Participante

TU/e

214.54K€ | Participante

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Duración del proyecto: 83 meses Fecha Inicio: 2018-05-24
Fecha Fin: 2025-04-30

Líder del proyecto

STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRU... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 3M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Collagen mineralization in bone is one of the most crucial processes in our body as it supplies the skeleton on which we depend for support and protection. Bone’s impressive mechanical properties arise from the hierarchical organization of the organic collagen matrix that is mineralized with ultrathin, aligned inorganic crystals of carbonated hydroxyapatite. Despite its importance to the human body, relatively little is understood about collagen mineralization and how the proteins govern mineral growth with such precision. This is because the matrix development is a complex process with different stages that occur over multiple length scales and depends on many different components. I propose to obtain the first comprehensive picture of the collagen mineralization mechanism by unraveling its dynamics and structural details. It is not only of great fundamental importance, it also opens the way to the development of better biomaterials, as well as to strategies for the treatment of mineralization-related diseases. I will achieve this ambitious goal by designing a dedicated tissue engineering platform that models real bone as closely as possible, and will allow application of multiple advanced analysis techniques. These I will employ in a Google Earth approach, studying the process from the micrometer to the nanometer scale, combining live cell imaging and beyond state-of-the-art electron microscopy with chemical and biochemical analysis to reveal the details of collagen mineralization with the highest spatial, temporal and molecular resolution thus far. Exploiting my extensive expertise in the field of biomineralization and advanced electron microscopy, COLMIN will provide a major step in understanding collagen formation and mineralization, and provide insights that will help to fight bone-related diseases. The advanced multidisciplinary methodology developed here will set a new standard for the advanced analysis of bone formation and other biological processes.

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