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3Dwheat

Financiado

3Dwheat, A 3 Dimensional functional genomics approach to identify hidden targets...

3Dwheat, A 3 Dimensional functional genomics approach to identify hidden targets controlling heat stress and priming in wheat In the global warming era, heat stress is a major threat for both yield stability and yield increase. Plants have evolved a variety of sophisticated mechanisms to adapt to challenging environments. Epigenetic regulations allow the... ver más

31/08/2027

UPCité

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

UNIVERSITE PARIS CITE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-06-23

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

ERC-2021-COG: ERC CONSOLIDATOR GRANTS

I+D

Cerrada hace 3 años

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1 Participantes

UPCité

2.00M€ | Lider

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Últimas noticias

29-11-2024: IDAE En las últimas 48 horas el Organismo IDAE ha otorgado 4 concesiones

29-11-2024: ECE En las últimas 48 horas el Organismo ECE ha otorgado 2 concesiones

29-11-2024: CMVAMADRID En las últimas 48 horas el Organismo CMVAMADRID ha otorgado 37 concesiones

Duración del proyecto: 62 meses Fecha Inicio: 2022-06-23
Fecha Fin: 2027-08-31

Líder del proyecto

UNIVERSITE PARIS CITE

TRL 4-5

Presupuesto del proyecto 2M€

Descripción del proyecto In the global warming era, heat stress is a major threat for both yield stability and yield increase. Plants have evolved a variety of sophisticated mechanisms to adapt to challenging environments. Epigenetic regulations allow them to dynamically reprogram their transcription machinery to adapt to an ever-changing environment. Both histone marks and the 3D organization of the chromatin are instrumental for this coordinated regulation of gene expression according to environmental cues. Yet, the overwhelming majority of available data on chromatin dynamics in response to stress has been obtained in Arabidopsis, and cannot be directly transferred to crops. Due to the expansion of NGS technologies, we are currently facing a change of paradigm, empowering the development of genome-wide approaches on crops. In this project we focus on wheat. Wheat is the 1st cereal worldwide for trade, and the demand is expected to increase by 60% by 2050. My main objective is a thorough understanding of the priming for heat stress resistance in wheat. To this end, I propose to develop a new tri-dimensional (D) functional genomics approach, integrating epigenomic (1D), transcriptomic (2D) and chromatin architecture (3D) data to elucidate the molecular basis for priming in wheat. Moreover, this project will go beyond addressing the challenge of deciphering epigenetic regulatory processes underlying priming. It also includes the development of innovative tools for novel breeding strategies that will harness epigenetic variability in addition to genetic diversity. We propose to generate a new generation of molecular markers that do not rely on DNA sequence polymorphisms, and that can be readily used in traditional breeding programs as such, or as complementary tools for efficient QTL introgression. Such markers will be used to tag new traits, to follow a new generation of alleles as well as to unveil new types of genetic diversity in existing collections of germplasms.

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