The Francis Crick Institute
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DeepMechanism: Unravelling Signalling Heterogeneity using DEEP Learning and MECHANIstic Modelling
THE FRANCIS CRICK INSTITUTE LIMITED
tramitó un
HORIZON EUROPE:
ERC-2024-STG
Signalling enables cells to respond to external cues, but the inherent heterogeneity of individual cell responses,essential for multicellula...
2024-10-01 - 2029-09-30 | Financiado
2024-10-01 - 2029-09-30 | Financiado
DeepMechanism: Unravelling Signalling Heterogeneity using DEEP Learning and MECHANIstic Modelling
THE FRANCIS CRICK INSTITUTE LIMITED
tramitó un
HORIZON EUROPE:
ERC-2024-STG
Signalling enables cells to respond to external cues, but the inherent heterogeneity of individual cell responses,
essential for multicellul...
2024-09-05 - 2029-09-30 | Financiado
2024-09-05 - 2029-09-30 | Financiado
OMRP: O-Glc-NAc modifications of RNA-binding proteins
THE FRANCIS CRICK INSTITUTE LIMITED
participó en un
HORIZON EUROPE:
HORIZON-WIDERA-2022-TALENTS-04
O-GlcNAcylation is a post-translational dynamic modification of proteins that is becoming more widely recognized as a modification that can...
2023-05-11 - 2025-08-31 | Financiado
2023-05-11 - 2025-08-31 | Financiado
RETROFIT: Pinpointing novel molecular and cellular functions generated by retroelement onco exaptation
THE FRANCIS CRICK INSTITUTE LIMITED
tramitó un
H2020:
ERC-2020-ADG
Exaptation, the co-option of endogenous retroelements (EREs) for new molecular and cellular functions that confer a host fitness advantage,...
2021-11-28 - 2026-11-30 | Financiado
2021-11-28 - 2026-11-30 | Financiado
CAN_ORGANISE: Understanding and controlling the spatial organisation of cancer
THE FRANCIS CRICK INSTITUTE LIMITED
tramitó un
H2020:
ERC-2020-ADG
The spatial of organisation of tumours is the cumulative result of a myriad of cell-cell and cell-matrix interactions. These interactions de...
2021-09-14 - 2026-09-30 | Financiado
2021-09-14 - 2026-09-30 | Financiado
PancObese: Metabolic mechanisms underpinning obesity driven pancreatic cancer
THE FRANCIS CRICK INSTITUTE LIMITED
tramitó un
H2020:
ERC-2020-ADG
Pancreatic cancer is one of the most lethal malignancies, showing a high rate of metastatic spread and a dismal prognosis. With almost no ef...
2021-07-14 - 2026-08-31 | Financiado
2021-07-14 - 2026-08-31 | Financiado
MeChroRep: Mechanism of Chromatin Replication
THE FRANCIS CRICK INSTITUTE LIMITED
tramitó un
H2020:
ERC-2020-ADG
Each time a human cell divides, it must make an exact copy of its 46 chromosomes. This requires precise duplication of ~6 billion base pairs...
2021-06-13 - 2027-04-30 | Financiado
2021-06-13 - 2027-04-30 | Financiado
MechHelicaseActiv8on: Unravelling the mechanism of eukaryotic helicase activation
THE FRANCIS CRICK INSTITUTE LIMITED
tramitó un
H2020:
H2020-MSCA-IF-2020
The initiation of DNA replication requires dynamic biomolecular interactions, which are temporally and spatially regulated to allow genome d...
2021-04-27 - 2024-08-31 | Financiado
2021-04-27 - 2024-08-31 | Financiado
DNA-Rep-EM: Origin dependent DNA replication visualised by Cryo EM
THE FRANCIS CRICK INSTITUTE LIMITED
tramitó un
H2020:
H2020-MSCA-IF-2020
Genome duplication is essential for cell proliferation. Errors in the mechanisms that control DNA replication can cause genomic instability...
2021-04-13 - 2024-08-31 | Financiado
2021-04-13 - 2024-08-31 | Financiado
TxImmuneOrganoids: Divide and conquer using patient derived tumour organoids to dissect intra tumour immune heterogene...
THE FRANCIS CRICK INSTITUTE LIMITED
tramitó un
H2020:
H2020-MSCA-IF-2020
Immune checkpoint blockade (ICB) has revolutionised treatment of patients with non-small cell lung cancer (NSCLC), but is effective in only...
2021-03-30 - 2023-07-31 | Financiado
2021-03-30 - 2023-07-31 | Financiado
TRIM MAGE complexes: Deciphering the mechanism of the dual functional E3 ligase TRIM28 in cancer cells
THE FRANCIS CRICK INSTITUTE LIMITED
tramitó un
H2020:
H2020-MSCA-IF-2020
TRIM family proteins are RING-type E3 ubiquitin ligases with important roles in immune responses, autophagy and cellular signalling. They ar...
2021-03-17 - 2023-03-31 | Financiado
2021-03-17 - 2023-03-31 | Financiado
JNK_Life.Death: Role of dynamic JNK signalling in balancing cell removal and renewal in a stressed epithelium
THE FRANCIS CRICK INSTITUTE LIMITED
tramitó un
H2020:
H2020-MSCA-IF-2020
Tissue homeostasis requires a tight maintenance of cell number. Little is known about how tissue size and cell numbers are maintained in str...
2021-03-17 - 2024-12-31 | Financiado
2021-03-17 - 2024-12-31 | Financiado
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