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MUSCLE-QC: Understanding the molecular basis of protein folding disorders and protein quality control in muscle FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH processed a HORIZON EUROPE: ERC-2023-ADG Mutations in certain proteins can cause their misfolding and aggregation, posing a potential threat to the health of an organism. Protein ag...
2025-01-01 - 2029-12-31 | financed

DYNAMORPH: Coupling morphogen dynamics with mechanics in the control of form and pattern FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH processed a HORIZON EUROPE: ERC-2023-STG Embryogenesis entails both the generation of cell type diversity and large-scale morphogenetic movements sculpting the forming body axes. Ho...
2024-08-01 - 2029-07-31 | financed

DYNAMORPH: Coupling morphogen dynamics with mechanics in the control of form and pattern FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH processed a HORIZON EUROPE: ERC-2023-STG Embryogenesis entails both the generation of cell type diversity and large-scale morphogenetic movements sculpting the forming body axes. Ho...
2024-07-30 - 2029-07-31 | financed

Adaptmet: Deconstructing adaptive evolution of metastasis Adaptmet aims to develop an advanced training program encompassing the multifaceted aspects of metastasis adaptation mechanisms, intending t...
2024-07-05 - 2029-02-28 | financed

UnlockIT: Unlocking a T cell-mediated Immune response in therapy-challenged Tumors FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH processed a HORIZON EUROPE: ERC-2023-COG Immuno- and targeted therapies have revolutionized the treatment of cancer patients, and more innovative therapeutics, such as KRAS inhibito...
2024-07-01 - 2029-06-30 | financed

UnlockIT: Unlocking a T cell mediated Immune response in therapy challenged Tumors FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH processed a HORIZON EUROPE: ERC-2023-COG Immuno- and targeted therapies have revolutionized the treatment of cancer patients, and more innovative therapeutics, such as KRAS inhibito...
2024-06-03 - 2029-06-30 | financed

mRNApackex: Mechanisms of human mRNA packaging and export FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH processed a HORIZON EUROPE: HORIZON-MSCA-2023-PF-01 The export of mRNA from the nucleus to the cytoplasm is an essential step in eukaryotic gene expression. This process requires that only ful...
2024-03-20 - 2026-04-30 | financed

GUARDIANS: Guard-driven immunity against pathogens FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH processed a HORIZON EUROPE: ERC-2023-STG Successful pathogens use virulence factors to inhibit immune defenses. To counteract this, host guard proteins monitor the integrity of path...
2024-01-01 - 2028-12-31 | financed

DeconstrucTolerance: Deconstructing Intestinal Immune Tolerance FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH processed a HORIZON EUROPE: ERC-2023-STG The intestinal tract is the main site of nutrient absorption and faces constant exposure to complex environmental stimuli. Intestinal barrie...
2024-01-01 - 2028-12-31 | financed

immunoMet: Deciphering immune evasion mechanisms of metastatic cancer cells using CRISPRa-inducible reporters FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH processed a HORIZON EUROPE: HORIZON-MSCA-2022-PF-01 Most cancer patients are resistant to immunotherapies, especially patients with liver and bone metastases. This suggests that during metasta...
2023-04-13 - 2026-08-31 | financed

GaMe: Mechanism of vertebrate sperm-egg recognition and fusion FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH processed a HORIZON EUROPE: ERC-2021-COG The life of every sexually reproducing being can be traced back to a singular event: the fusion of sperm and egg. Gamete fusion is perhaps t...
2023-01-01 - 2027-12-31 | financed

Cohesin-Tx: Cohesin Therapeutics. Precision medicine for treating STAG2 mutated cancers FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH processed a HORIZON EUROPE: ERC-2022-POC1 The cohesin gene STAG2 has emerged as a new tumour suppressor frequently mutated in bladder cancer, Ewing sarcoma and acute myeloid leukaemi...
2022-06-01 - 2024-05-31 | financed

LoopMechRegFun: Mechanism regulation and functions of genome folding through loop extrusion by cohesin NIPBL FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH processed a H2020: ERC-2020-ADG Since its discovery 150 years ago, DNA has been intensely studied. As a result, it is understood in some detail how genomic DNA is replicate...
2021-06-13 - 2026-09-30 | financed

mcMINFLUX: Tracking conformational dynamics of cohesin with MINFLUX FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH processed a H2020: H2020-MSCA-IF-2020 The DNA contained in each of our cells has a size of about 2 m and is fitted into the nucleus which is about six orders of magnitude smaller...
2021-04-22 - 2024-02-29 | financed

FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOL...