HORIZON EUROPE
Europeo
Specific Challenge:The prevalence of obesity is increasing and affects more than 650 million people of all ages to become one of the foremost global health threats. Obesity is complex and we only have a crude understanding of its underlying causes and biology, how to best describe and define it. Currently we have no way of predicting who will respond to or benefit from what kind of treatment or intervention.
Obesity can seriously impair health through a broad range of complications such as cardiovascular disease, type 1 and 2 diabetes (T1D and T2D), cancer, musculoskeletal disorders, psychosocial imbalances, and reduced quality of life, and impacts the treatment of other conditions.
There is therefore a need to better understand obesity and define clinically meaningful and relevant subgroups as a premise for optimising future prevention and treatment of obesity and its complications.
For complete information please see the IMI2 Call 17 topic text.
Scope:The overall aim is to identify pathophysiologically and clinically meaningful subgroups of obesity that will allow for optimisation of prevention and treatment of obesity an...
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Specific Challenge:The prevalence of obesity is increasing and affects more than 650 million people of all ages to become one of the foremost global health threats. Obesity is complex and we only have a crude understanding of its underlying causes and biology, how to best describe and define it. Currently we have no way of predicting who will respond to or benefit from what kind of treatment or intervention.
Obesity can seriously impair health through a broad range of complications such as cardiovascular disease, type 1 and 2 diabetes (T1D and T2D), cancer, musculoskeletal disorders, psychosocial imbalances, and reduced quality of life, and impacts the treatment of other conditions.
There is therefore a need to better understand obesity and define clinically meaningful and relevant subgroups as a premise for optimising future prevention and treatment of obesity and its complications.
For complete information please see the IMI2 Call 17 topic text.
Scope:The overall aim is to identify pathophysiologically and clinically meaningful subgroups of obesity that will allow for optimisation of prevention and treatment of obesity and its complications. This will be done by pooling cohorts from observational or interventional studies to establish a federated database with enough clinical phenotyping and multi-omics data for a data-driven stratification of obesity into subgroups. It will also address specifically type 1 diabetes (T1D) and type 2 diabetes (T2D) as examples of conditions in which both clinical phenotype and treatment is influenced by obesity in an intricate manner, including public education about obesity in T1D.
For complete information please see the IMI2 Call 17 topic text.
Expected Impact:This topic should pave the way for an optimised and more personalised future obesity treatment. Deciphering the heterogeneity of obesity and the potentially differential effect of weight loss and weight maintenance should lead for instance to:
increased understanding and respect for obesity as a chronic disease entity;potential for novel and innovative diagnostics for classification and evaluation of the obesity disease;increased potential to contribute to the development of more targeted prevention and lifestyle interventions;increased potential to develop targeted delivery of safe and effective treatments to clinically meaningful subgroups of patients with obesity;increased understanding of how obesity impacts other diseases as exemplified by impact on incidence, characteristics, treatment, costs, and outcomes of e.g. T1D. For complete information please see the IMI2 Call 17 topic text.
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Características del consorcio
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La ayuda es de ámbito europeo, puede aplicar a esta linea cualquier empresa que forme parte de la Comunidad Europea.
Características del Proyecto
Los costes de personal subvencionables cubren las horas de trabajo efectivo de las personas directamente dedicadas a la ejecución de la acción. Los propietarios de pequeñas y medianas empresas que no perciban salario y otras personas físicas que no perciban salario podrán imputar los costes de personal sobre la base de una escala de costes unitarios
Los otros costes directos se dividen en los siguientes apartados: Viajes, amortizaciones, equipamiento y otros bienes y servicios. Se financia la amortización de equipos, permitiendo incluir la amortización de equipos adquiridos antes del proyecto si se registra durante su ejecución. En el apartado de otros bienes y servicios se incluyen los diferentes bienes y servicios comprados por los beneficiarios a proveedores externos para poder llevar a cabo sus tareas
La subcontratación en ayudas europeas no debe tratarse del core de actividades de I+D del proyecto. El contratista debe ser seleccionado por el beneficiario de acuerdo con el principio de mejor relación calidad-precio bajo las condiciones de transparencia e igualdad (en ningún caso consistirá en solicitar menos de 3 ofertas). En el caso de entidades públicas, para la subcontratación se deberán de seguir las leyes que rijan en el país al que pertenezca el contratante
Características de la financiación
The IMI2 JU 17th Call for proposals topics text as well as the Call Conditions are available here
The budget breakdown for this Call is given at the end of the Call topics text, in the Call conditions section, as well as the following information :
1. Eligible countries: described in article 10(2) of the Rules for participation in Horizon 2020 and in article 1 of the Commission Delegated Regulation related to IMI JU.
2. Eligibility and admissibility conditions: described in the IMI2 Manual for evaluation, submission and grant award. See also the Commission Delegated Regulation related to IMI JU.
Proposal page limits and layout: Please refer to Part B of the proposal template in the submission tool below.
3. Evaluation:
Submission and evaluation process, including evaluation criteria and procedure, scoring and threshold are described in the IMI2 Manual for submission, evaluation and grant award. See also the proposal templates for your specific action in section 5, below.
4. Indicative time for evaluation and grant agreement:
Notification of outcomes of stage 1 evaluations: maximum 5 months from deadline for submitting proposals.
The IMI2 JU 17th Call for proposals topics text as well as the Call Conditions are available here
The budget breakdown for this Call is given at the end of the Call topics text, in the Call conditions section, as well as the following information :
1. Eligible countries: described in article 10(2) of the Rules for participation in Horizon 2020 and in article 1 of the Commission Delegated Regulation related to IMI JU.
2. Eligibility and admissibility conditions: described in the IMI2 Manual for evaluation, submission and grant award. See also the Commission Delegated Regulation related to IMI JU.
Proposal page limits and layout: Please refer to Part B of the proposal template in the submission tool below.
3. Evaluation:
Submission and evaluation process, including evaluation criteria and procedure, scoring and threshold are described in the IMI2 Manual for submission, evaluation and grant award. See also the proposal templates for your specific action in section 5, below.
4. Indicative time for evaluation and grant agreement:
Notification of outcomes of stage 1 evaluations: maximum 5 months from deadline for submitting proposals.
Notification of outcomes of stage 2 evaluations: maximum 5 months from deadline for submitting full proposals.
Signature of grant agreements: maximum 3 months from the date of informing successful applicants.
5. Proposal templates, evaluation forms and model grant agreements (MGA):
IMI2 Research and Innovation Action (IMI2-RIA) and Innovation Action (IMI2-IA):
Proposal templates are available after entering the submission tool
Standard evaluation form
IMI2 Model Grant Agreement
Clinical trial template – the Clinical Trial template is compulsory at stage 2 only !
6. Open access must be granted to all scientific publications resulting from Horizon 2020 actions.
Where relevant, proposals should also provide information on how the participants will manage the research data generated and/or collected during the project, such as details on what types of data the project will generate, whether and how this data will be exploited or made accessible for verification and re-use, and how it will be curated and preserved.
Open access to research data
The Open Research Data Pilot has been extended to cover all Horizon 2020 topics for which the submission is opened on 26 July 2016 or later. Projects funded under this topic will therefore by default provide open access to the research data they generate, except if they decide to opt-out under the conditions described in Annex L of the H2020 main Work Programme. Projects can opt-out at any stage, that is both before and after the grant signature.
Note that the evaluation phase proposals will not be evaluated more favourably because they plan to open or share their data, and will not be penalised for opting out.
Open research data sharing applies to the data needed to validate the results presented in scientific publications. Additionally, projects can choose to make other data available open access and need to describe their approach in a Data Management Plan.
Projects need to create a Data Management Plan (DMP), except if they opt-out of making their research data open access. A first version of the DMP must be provided as an early deliverable within six months of the project and should be updated during the project as appropriate. The Commission already provides guidance documents, including a template for DMPs. See the Online Manual.
Eligibility of costs: costs related to data management and data sharing are eligible for reimbursement during the project duration.
The legal requirements for projects participating in this pilot are in the article 29.3 of the Model Grant Agreement.
Members of consortium are required to conclude a consortium agreement prior to the signature of the grant agreement.
7. Additional documents:
Summary of the most relevant provisions for participating in IMI2 actions
2019 Annual Work Plan and Budget
IMI2 Regulators Guidance tool for researchers
IMI JU derogation to H2020 Rules for Participation
Horizon 2020 Rules for Participation
Horizon 2020 Regulation of Establishment
Horizon 2020 Specific Programme
Información adicional de la convocatoria
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