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ZeNewCardio

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ZeNewCardio Discovering Heart Regeneration Therapies Through Zebrafish

Ischemic heart disease is a leading cause of death worldwide. However, heart transplantation is risky, plus the number of donors does not cover the demand of patients, and alternative treatments are inefficient. Given that adult m... see more

31/05/2021

ZECLINICS

161K€

Project Budget: 161K€

Project leader

ZECLINICS La investigacion y desarrollo experimental en ciencias naturales,tecnicas ybiotecnologia

TRL 3-4 | 260K€

PARTICIPATION DEPralty Sin fecha límite de participación.

Financing granted El organismo H2020 notifico la concesión del proyecto The day 2021-05-31

MSCA-IF-2018: Individual Fellowships Objective:The goal of the Individual Fellowships is to enhance the creative and innovative potential...

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Cerrada does 6 years

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characteristics of the participant

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

Private Information

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

ZECLINICS

160.93K€ | Leader

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Project duration: 25 months Date Start: 2019-04-03
End date: 2021-05-31

Project leader

ZECLINICS La investigacion y desarrollo experimental en ciencias naturales,tecnicas ybiotecnologia

TRL 3-4 | 260K€

Project Budget 161K€

participation deadline Sin fecha límite de participación.

Project description Ischemic heart disease is a leading cause of death worldwide. However, heart transplantation is risky, plus the number of donors does not cover the demand of patients, and alternative treatments are inefficient. Given that adult mammalian hearts display insufficient regeneration capability to allow complete myocardial recovery, a promising treatment after infarction could be the identification of molecules unblocking cardiac self-healing/regeneration. In that sense, zebrafish displays life-long ability to regenerate its heart after damage. Interestingly, the same genetic programs promoting cardiomyocyte dedifferentiation and proliferation after injury in zebrafish are present, albeit dormant, in the adult mammalian heart. This makes zebrafish a powerful model to unravel key molecular pathways that might induce heart regeneration in humans, if activated. Here, we propose the development of ZeNewCardio: a high-throughput preclinical platform using the zebrafish model to find suitable treatments for heart regeneration after ischemia. The project aims are: 1) to implement cardiac injury models in zebrafish; 2) to use these models to identify genes involved in heart regeneration, with a focus on genes enabling cardiomyocyte dedifferentiation/proliferation; 3) to use the gathered knowledge to discover novel cardiac pro-regeneration drug therapies applicable to humans. Our genetic and analysis tools will speed-up the process of target validation of novel gene regulators of regeneration, based on the stimulation of endogenous regenerative responses, and the discovery of new drug therapies to treat or protect ischemic hearts.

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