NeuroVisEco
Financiado
Zebrafish vision in its natural context from natural scenes through retinal and...
Zebrafish vision in its natural context from natural scenes through retinal and central processing to behaviour.
All visual systems are specialised to best serve an animal’s sensory niche, yet how such specialisations are achieved through phylogenetic and developmental adaptations of the ‘common vertebrate visual system blueprint’ are poorly...
All visual systems are specialised to best serve an animal’s sensory niche, yet how such specialisations are achieved through phylogenetic and developmental adaptations of the ‘common vertebrate visual system blueprint’ are poorly understood. I will study these adaptations in the visual system of zebrafish. I will use two-photon functional imaging and computational modelling to investigate how the visual system of zebrafish samples and processes behaviourally meaningful stimuli in the natural world. I will then use optogenetic manipulations while zebrafish navigate a virtual reality environment to directly probe the role of visual circuits in driving behaviour. Specifically, I will pursue four Aims:
1. What is the zebrafish eye designed to see?
2. How does the fish retina form feature selective output channels?
3. What does the fish’s eye tell the fish’s brain?
4. How does visual input to the brain lead to behaviour?
Visual specialisations begin in the optics and movements of the eyes, and are subsequently deeply rooted in every step of neuronal computation. Therefore, I will study visual processing at these different organisational levels. Here, the highly ‘visual’ zebrafish present a powerful model. They (i) offer exquisite genetic tools to record and manipulate neurons, (ii) have transparent larval stages permitting optical access to the entire nervous system and (iii) there is a large array of well-studied and easily quantifiable visual behaviours. In addition, zebrafish undergo two distinct life-stages, from larva to adult - with distinct lifestyles in different visual environments and hence different feature-detection requirements. Comparison of processing strategies employed by the (a) larval and (b) adult zebrafish visual system with that of other species, including a complementary database already recorded in mice (c), will lead to an increasingly generalised understanding of biological vision.
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Duración del proyecto: 73 meses
Fecha Inicio: 2016-04-22
Fecha Fin: 2022-05-31
Fecha Fin: 2022-05-31
Línea de financiación: concedida
El organismo H2020 notifico la concesión del proyecto el día 2022-05-31
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
ERC-StG-2015:
ERC Starting Grant
Cerrada
hace 9 años
Presupuesto
El presupuesto total del proyecto asciende a
2M€
Líder del proyecto
THE UNIVERSITY OF SUSSEX
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5
299.74K€ |
Participante