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AstroWireSyn

Financiado

Wiring synaptic circuits with astroglial connexins mechanisms dynamics and imp...

Wiring synaptic circuits with astroglial connexins mechanisms dynamics and impact for critical period plasticity Brain information processing is commonly thought to be a neuronal performance. However recent data point to a key role of astrocytes in brain development, activity and pathology. Indeed astrocytes are now viewed as crucial element... ver más

31/03/2022

COLLEGE DE FRANCE

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

COLLEGE DE FRANCE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 3 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2022-03-31

ERC-CoG-2015: ERC Consolidator Grant

I+D

Cerrada hace 9 años

0% 100% 100%

3 Participantes

COLLEGE DE FRANCE

2.00M€ | Lider

NATURA BISSE INTERNATIONAL

325.75K€ | Participante

INSERM

412.50K€ | Participante

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Duración del proyecto: 66 meses Fecha Inicio: 2016-09-08
Fecha Fin: 2022-03-31

Líder del proyecto

COLLEGE DE FRANCE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Descripción del proyecto Brain information processing is commonly thought to be a neuronal performance. However recent data point to a key role of astrocytes in brain development, activity and pathology. Indeed astrocytes are now viewed as crucial elements of the brain circuitry that control synapse formation, maturation, activity and elimination. How do astrocytes exert such control is matter of intense research, as they are now known to participate in critical developmental periods as well as in psychiatric disorders involving synapse alterations. Thus unraveling how astrocytes control synaptic circuit formation and maturation is crucial, not only for our understanding of brain development, but also for identifying novel therapeutic targets. We recently found that connexin 30 (Cx30), an astroglial gap junction subunit expressed postnatally, tunes synaptic activity via an unprecedented non-channel function setting the proximity of glial processes to synaptic clefts, essential for synaptic glutamate clearance efficacy. Our work not only reveals Cx30 as a key determinant of glial synapse coverage, but also extends the classical model of neuroglial interactions in which astrocytes are generally considered as extrasynaptic elements indirectly regulating neurotransmission. Yet the molecular mechanisms involved in such control, its dynamic regulation by activity and impact in a native developmental context are unknown. We will now address these important questions, focusing on the involvement of this novel astroglial function in wiring developing synaptic circuits. Thus using a multidisciplinary approach we will investigate: 1) the molecular and cellular mechanisms underlying Cx30 regulation of synaptic function 2) the activity-dependent dynamics of Cx30 function at synapses 3) a role for Cx30 in wiring synaptic circuits during critical developmental periods This ambitious project will provide essential knowledge on the molecular mechanisms underlying astroglial control of synaptic circuits.

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