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BacterialCORE

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Widespread Bacterial CORE Complex Executes Intra and Inter Kingdom Cytoplasmic...

Widespread Bacterial CORE Complex Executes Intra and Inter Kingdom Cytoplasmic Molecular Trade The enormous versatility of bacteria enables the formation of multi-species communities that colonize nearly every niche on earth, making them the dominant life form and a major component of the biomass. Exchange of molecular info... ver más

31/03/2025

THE HEBREW UNIVERS...

7M€

Presupuesto del proyecto: 7M€

Líder del proyecto

THE HEBREW UNIVERSITY OF JERUSALEM No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 3 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2018-12-11

ERC-2018-SyG: ERC Synergy Grant

I+D

Cerrada hace 7 años

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No hay información privada compartida para este proyecto. Habla con el coordinador.

3 Participantes

THE HEBREW UNIVERSITY OF JER...

6.38M€ | Lider

TEK TRANSLATION INTERNATIONA...

BIRKBECK COLLEGE UNIVERSITY...

546.06K€ | Participante

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Duración del proyecto: 75 meses Fecha Inicio: 2018-12-11
Fecha Fin: 2025-03-31

Líder del proyecto

THE HEBREW UNIVERSITY OF JERUSALEM No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 7M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The enormous versatility of bacteria enables the formation of multi-species communities that colonize nearly every niche on earth, making them the dominant life form and a major component of the biomass. Exchange of molecular information among neighboring bacteria in such communities, as well as between bacteria and proximal eukaryotic cells, is key for bacterial success. Yet, the principles controlling these multicellular interactions are poorly defined. Here we describe the identification of a bacterial protein complex, herein termed CORE, whose function is to traffic cytoplasmic molecules among different bacterial species, and between pathogenic bacteria and their human host cells. The CORE is composed of five membrane proteins, highly conserved across the entire bacterial kingdom, providing a ubiquitous platform that facilitates both intra- and inter-kingdom crosstalk. Our preliminary data support the idea that the CORE acts as a shared module for the assembly of larger apparatuses, executing this universal molecular flow among organisms. We propose to elucidate components, structure and biogenesis of the CORE machinery, operating during bacteria-bacteria and pathogen-host interactions. We further aim to provide an unbiased-global view of the extent and identity of cytoplasmic molecules traded via CORE including metabolites, proteins and RNA, and to reveal the criteria determining the specificity of the transported cargo. Furthermore, we intend to decipher the impact of CORE-mediated molecular exchange on bacterial physiology and virulence, and devise anti-CORE compounds to combat pathogenic bacteria. This study is expected to transform the way we currently view bacterial communities and host-pathogen interactions. We anticipate these findings to lead to the development of creative strategies to modulate, predict and even design bacterial communities, and lay the foundation for new and innovative approaches to fight bacterial diseases.

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