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OptoWave

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Waveguide-based Cochlear Implant for Optogenetic Stimulation

The optical cochlear implant (oCI) aims to restore near natural hearing in profoundly hearing impaired and deaf patients. Sound perception will be restored through an implantable medical device in combination with a gene therapy m... see more

31/08/2024

UMG

Unknown Budget

Project leader

UNIVERSITAETSMEDIZIN GOETTINGEN GEORGAUGUSTU... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

PARTICIPATION DEPralty Sin fecha límite de participación.

Financing granted El organismo HORIZON EUROPE notifico la concesión del proyecto The day 2024-08-31

ERC-2022-POC2: ERC PROOF OF CONCEPT GRANTS2 Objective:Objectives:

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Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

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Project duration: 17 months Date Start: 2023-03-01
End date: 2024-08-31

Project leader

UNIVERSITAETSMEDIZIN GOETTINGEN GEORGAUGUSTU... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

participation deadline Sin fecha límite de participación.

Project description The optical cochlear implant (oCI) aims to restore near natural hearing in profoundly hearing impaired and deaf patients. Sound perception will be restored through an implantable medical device in combination with a gene therapy medicinal product. Thereby the auditory nerve is stimulated directly through focused light replacing the dysfunctional or absent hair cells. This is achieved through combination of micro-scale light emitter technology and precise neural control through expression of light-gated ion channels in the auditory nerve (called optogenetics).Here, we propose to prove feasibility of an optical waveguide modules for future optical cochlear implants. Building on fabricating micro-scaled waveguide arrays, multi-beam laser diode emitters, we plan to couple them via micro-lens arrays in a compact multi-channel optical module for testing the feasibility of miniaturization and integration of the optical components. Preclinical validation shall be performed in rodents.The proposed waveguide-based optical module combines several aspects, which makes it a candidate for later clinical application. The optical emitters can be safely integrated in the hermetically sealed titanium package housing the internal oCI electronics. Thus, there is no need to directly insert the emitters in the cochlear turns, which mitigates the risk of heat impact on the patient during optical stimulation. Furthermore, emerging red light activated opsins can be addressed by readily available red laser diode technology.

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