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VOLUME-BIO

Financiado

Volumetric light driven bioprinting capturing complex physiological shape size...

Volumetric light driven bioprinting capturing complex physiological shape size and function in artificial tissues and organoids Lab-made artificial tissues and organoids promise to revolutionize medicine, tackling transplant shortage, and to innovate biological and pharmaceutical research, introducing accurate in vitro models of human physiology, as potent... ver más

31/12/2025

UMC UTRECHT

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

UNIVERSITAIR MEDISCH CENTRUM UTRECHT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 3 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2020-11-06

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

ERC-2020-STG: ERC STARTING GRANTS

I+D

Cerrada hace 5 años

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3 Participantes

UMC UTRECHT

1.55M€ | Lider

GUASCOR FOTON, S.L.

1.79M€ | Participante

315.62K€ | Participante

Últimas noticias

25-11-2024: ECE En las últimas 48 horas el Organismo ECE ha otorgado 52 concesiones

25-11-2024: CMVAMADRID En las últimas 48 horas el Organismo CMVAMADRID ha otorgado 1 concesiones

25-11-2024: FUNDACION-EOI En las últimas 48 horas el Organismo FUNDACION EOI ha otorgado 6 concesiones

Duración del proyecto: 61 meses Fecha Inicio: 2020-11-06
Fecha Fin: 2025-12-31

Líder del proyecto

UNIVERSITAIR MEDISCH CENTRUM UTRECHT

TRL 4-5

Presupuesto del proyecto 2M€

Descripción del proyecto Lab-made artificial tissues and organoids promise to revolutionize medicine, tackling transplant shortage, and to innovate biological and pharmaceutical research, introducing accurate in vitro models of human physiology, as potential alternatives to animal experimentation. The functionality of living organs is intimately linked to their complex architecture, from the physicochemical properties of extracellular microenvironment, to tissue-level scale, where multiple cell populations interact in a precisely orchestrated spatial distribution. Advances in key technologies capturing this shape-function relationship in vitro can bring the long-sought goal of real tissue engineering within reach. In VOLUME-BIO I will develop a novel multi-material volumetric bioprinting technology for the precise generation of engineered tissues and organoids exhibiting physiological functions. Inspired by optical tomography, cell-laden hydrogels are sculpted into tissue analogues within seconds, upon exposure to bio-friendly 3D visible light fields. Tuneable light patterns control the local distribution of cells and, through orthogonal photo-chemical reactions, of key factors that guide stem cell fate, namely stiffness of the extracellular matrix and morphogenetic biochemical cues. The unprecedented ability to tune independently such parameters will also permit to build 3D platforms to study how architectural complexity impacts organoid maturation. This will provide a new tool to address the so far unanswered question of how much an engineered tissue needs to mimic Nature’s template to achieve physiological functionality. Bringing together my expertise in engineering, bioprinting, materials design and stem cell biology, I will first test the potential and versatility of this novel volumetric technology by building from anatomical patient-specific images functional and centimetre-scale vascularized bone and bone marrow organoid supporting physiological-like hematopoiesis.

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