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Visual genetics establishment of a new discipline to visualize neuronal nuclear...

Visual genetics establishment of a new discipline to visualize neuronal nuclear functions in real time in intact nervous system by 4D Raman spectroscopy Due to technical constraints the observation and analysis of endogenous transcriptional processes in living and functioning organisms is not feasible today. Therefore our understanding of the nuclear processes and the options to d... ver más

30/11/2022

UoB

4M€

Presupuesto del proyecto: 4M€

Líder del proyecto

THE UNIVERSITY OF BIRMINGHAM No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

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Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2022-11-30

FETOPEN-RIA-2014-2015: FET-Open research projects Scope:Specific challenge: Supporting a large set of early stage, high risk visionary science and tec...

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Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

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5 Participantes

UoB

722.32K€ | Lider

Wigner RCP

712.25K€ | Participante

MPG

711.00K€ | Participante

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Duración del proyecto: 78 meses Fecha Inicio: 2016-05-26
Fecha Fin: 2022-11-30

Líder del proyecto

THE UNIVERSITY OF BIRMINGHAM No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 4M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Due to technical constraints the observation and analysis of endogenous transcriptional processes in living and functioning organisms is not feasible today. Therefore our understanding of the nuclear processes and the options to diagnose or intervene at genetic level is seriously constrained. Our proposal offers a cutting-edge technique to overcome this limitation. The aim is to visualize nuclear processes in intact brain in real-time leading to a new high-tech product development, prototype scientific equipment at the research institutes and in the long run new tools to study and cure human diseases. The main objectives are to: 1) develop Stimulated Raman Spectroscopy (SRS)-based technologies to visualize endogenous transcription at single cell and single locus gene level; 2) develop tools for loading alkyne-tagged nucleosides and nucleotide analogues into cells; 3) distinguish various cells including neuron types without labelling by SRS; 4) track transcription processes in intact cells with high temporal and spatial resolution; 5) develop and commercialise a 4D-SRS microscope for broad range of applications. The combination of label-free neuron mapping and visualization of nuclear activity at single locus gene level provides a new level of information of the structural and functional organization of the organism. The genetic basis of most of the diseases is still unknown. Widening genetic knowledge of diseases will offer as yet unknown therapeutic possibilities. Understanding the neural processes at the genetic level offer the possibility to intervene at that deep level, targeting not only the symptoms but the cause. The proposed novel technology provides new insight to understand for example neural networks and is a key to understand and treat for example nervous system dysfunctions. The 4D-SRS systems can be utilized for other medical-based research and development projects aimed at early stage disease diagnosis, cancer detection, and toxicity studies.

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